Anti-Glutaredoxin-1 antibody produced in rabbit

NA.41

Glutaredoxin-1 (Grx1) is encoded by the gene mapped to human chromosome 5q15. The encoded protein is a sulfhydryl disulfide oxidoreductase enzyme with a molecular mass of 12kDa. Grx1 belongs to the oxidoreductase family. Grx is expressed in various types of mammalian cells including human placenta and erythrocytes.
Anti-Glutaredoxin-1 is produced in rabbit using as immunogen a human glutaredoxin-1 recombinant protein (G5298), conjugated to KLH. GRX1 is found in the cytosol and supplies ribonucleotide reductase with electrons.

human glutaredoxin-1 recombinant protein conjugated to KLH

Anti-Glutaredoxin-1 antibody produced in rabbit has been used in immunoblotting.

Glutaredoxin (Grx) catalyzes glutathione (GSH)-dependent disulfide reductions when coupled to GSH, NADPH and glucocorticoid receptor (GR). Grx1 is implicated in various cellular processes, such as anti-oxidation, anti-apoptosis and regulation of cell differentiation. Additionally, the encoded protein also protects the retinal pigment epithelial (RPE) cells from H₂O₂-induced apoptosis by inhibiting protein kinase B (AKT) glutathionylation. Thus, Grx1 can be used as a potential therapeutic target for retinal degenerative diseases.
GRX1 is involved in general disulfide-dithiol exchanges, dehydroascorbate reduction and regulation of transcription factors.

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide as a preservative

rabbit

200

unconjugated

Ig fraction of antiserum

primary antibodies

polyclonal

buffered aqueous solution

~12 kDa

human

western blot: 1:500-1:1000 using whole extracts of human HepG2 cells

P35754

dry ice

−20℃

human ... GLRX(2745)

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12 - Non Combustible Liquids