Anti-Glycine Receptor antibody produced in rabbit

MFCD01864445

NA.41

The GLRA1 (glycine receptor α 1) gene is mapped to human chromosome 5q33.1. Glycine receptor is a pentameric Cys-loop ligand-gated ion channel. It is a transmembrane protein, with its five subunits arranged around a central water-filled Cl−selective pore. The protein is expressed all over the nervous system. Each of its subunit contains four transmembrane (TM) segments with an intracellular loop connecting TM3 and TM4, and an extracellular ligand binding domain.

The antibody recognizes the α1 glycine receptor and cross-reacts with human α2 glycine receptor subunits.

synthetic peptide from the amino terminus of the human α1 glycine receptor subunit.

Anti-Glycine Receptor antibody is suitable for western blot analysis of immunoprecipitates of rat spinal cord (lane 2) and human sperm extract in the detection of GlyR in human sperm.

Glycine receptors act as excitatory neurotransmitter as well as inhibitory receptor. It plays a central role in acrosome reaction (AR). Mutations in the GLRA1 gene encoding the α1-subunit of the glycine receptor causes startle disease (STHE), also known as hereditary hyperekplexia or congenital stiff-person syndrome.

Lyophilized powder from 5 mM ammonium bicarbonate.

rabbit

100

unconjugated

affinity isolated antibody

primary antibodies

polyclonal

lyophilized powder

human, rat

immunohistochemistry: 1-1000
western blot: 1-1000 using detects the alpha1 glycine receptor using rat spinal cord

P23415

2-8℃

human ... GLRA1(2741), GLRA2(2742)
rat ... Ptk2(25674)

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