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Anti-GPC1 antibody produced in rabbit
| 产品编号： | 3365564 |
| 规格： | affinity isolated antibody, buffered aqueous solution |
| 包装规格： | 100 μL |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-GPC1 antibody produced in rabbit
glypican
FLJ38078
GPC1
基本信息
| NACRES | NA.41 |
| General description【一般描述】 | Glypican 1 (GPC1) is located at 2q37.3 on the human chromosome. It belongs to the family of glycosylphosphatidylinositol-anchored heparan sulfate proteoglycan. GPC1 is localized in the vascular system. GPC1 consists of an N-terminal secretory signal peptide, 14 conserved cysteine residues, a heparan sulfate (HS) attachment domain near the C terminus and a hydrophobic domain for attachment of the glycosylphosphatidylinositol (GPI) at the C terminus. |
| Immunogen【免疫原】 | Recombinant protein encompassing a sequence within the center region of human Glypican 1. |
| Application【应用】 | Anti-GPC1 antibody produced in rabbit has been used in flow cytometry and immunostaining. |
| Biochem/physiol Actions【生化/生理作用】 | Glypican 1 (GPC1) plays an important role in cell growth, differentiation and morphogenesis. It also plays a role in cell migration, adhesion, anti-coagulation, lipoprotein metabolism and modulation of growth factors. GPC1 exhibits chaperone-like activity by restoring the binding activity of oxidized VEGF165 (vascular endothelial growth factors-165). Overexpression of GPC1 results in over accumulation of β-amyloid protein (Aβ) in the Alzheimer′s disease (AD) brain. Mutation in this gene is associated with Niemann-Pick C1 disease. |
| Features and Benefits【特点和优势】 | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| Physical form【外形】 | 1XPBS, 20% Glycerol (pH7). 0.025% ProClin 300 was added as a preservative. |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| form【形式】 | buffered aqueous solution |
| species reactivity | human, mouse |
| technique(s) | ELISA: suitable flow cytometry: suitable immunofluorescence: suitable immunohistochemistry: suitable immunoprecipitation (IP): suitable western blot: 500-3000 |
| NCBI accession no.【NCBI登记号】 | NP_002072 |
| UniProt accession no.【UniProt登记号】 | P35052 |
| application(s) | research pathology |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... GPC1(2817) |
产品说明
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Pictograms【象形图】 | GHS07 |
| Signal word【警示用语：】 | Warning |
| Hazard Statements | H317 - H412 |
| Precautionary Statements | P261 - P272 - P273 - P280 - P302 + P352 - P333 + P313 |
| Hazard Classifications【危险分类】 | Aquatic Chronic 3 - Skin Sens. 1 |
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 2 |
