Anti-GPC4 (N-term) antibody produced in rabbit

NA.41

GPC4 (glypican-4) gene is mapped to human chromosome Xq26.2. The encoded protein is a heparan sulfate proteoglycan and localizes to membrane microdomains.
Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The GPC4 gene is adjacent to the 3′ end of GPC3 and may also play a role in Simpson-Golabi-Behmel syndrome.

GPC4 (NP_001439, 30-66)
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-term region of human GPC4.

GPC4 (glypican-4) is associated with a number of signaling mechanisms involving growth factors. GPC4 influences cell proliferation, by serving as a co-receptor for growth factors. It regulates the Wnt signaling pathway. GPC4 might be associated with epileptic seizures, with this gene upregulated in the brain. GPC4 is an adipokine and is known to enhance insulin signaling and regulate adipocyte differentiation. Overexpression of this gene in polycystic ovary syndrome might be associated with the risk of cardiovascular disease.

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

rabbit

100

unconjugated

saturated ammonium sulfate (SAS) precipitated

primary antibodies

polyclonal

buffered aqueous solution

human

immunohistochemistry: 1:50-1:100
indirect ELISA: 1:1000

NP_001439

O75487

dry ice

−20℃

human ... GPC4(2239)

12 - Non Combustible Liquids

nwg