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Anti-Histone Deacetylase 2 (HDAC2) antibody, Mouse monoclonal
| 产品编号： | 3367632 |
| 规格： | clone HDAC2-62, purified from hybridoma cell culture |
| 包装规格： | 25 μL，100 μL，200 μL |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
基本信息
| MDL number | MFCD02096544 |
| NACRES | NA.41 |
| General description【一般描述】 | Anti-Histone Deacetylase 2 (HDAC2) antibody, Mouse monoclonal (mouse IgG2b isotype) is derived from the HDAC2-62 hybridoma produced by the fusion of mouse myeloma cells (NS1) and splenocytes from BALB/c mice immunized with a synthetic peptide corresponding to the C-terminal region of human histone deacetylase 2 (amino acid residues with N-terminal added cysteine) conjugated to maleimide-activated KLH. Histone deacetylase 2 (HDAC2) is the catalytic subunits of different multiprotein regulatory complexes. |
| Specificity【特异性】 | Monoclonal Anti-Histone Deacetylase 2 (HDAC2) recognizes human, bovine, dog, rat, mouse, and chicken HDAC2 (approx. 55 kDa). The antibody epitope resides within amino acids 471-488 of human HDAC2. |
| Application【应用】 | Anti-Histone Deacetylase 2 (HDAC2) antibody, Mouse monoclonal has been used in:
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| Biochem/physiol Actions【生化/生理作用】 | Histone Deacetylases including HDAC′s 1-10 facilitate transcriptional repression and nucleosome condensation. Abnormal recruitment of HDACs by various oncoproteins may occur in certain neoplastic diseases. Inhibition of HDAC2 activity by valproic acid induces proteasomal degradation of HDAC2. |
| Physical form【外形】 | Solution in 0.01 M phosphate buffered saline, pH 7.4, and 15 mM sodium azide. |
产品性质
| Quality Level【质量水平】 | 200 |
| biological source【生物来源】 | mouse |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | purified immunoglobulin |
| antibody product type | primary antibodies |
| clone【克隆】 | HDAC2-62, monoclonal |
| form【形式】 | buffered aqueous solution |
| mol wt【分子量】 | antigen ~55 kDa |
| species reactivity | rat, canine, human, chicken, mouse, bovine |
| technique(s) | immunohistochemistry: suitable immunoprecipitation (IP): suitable indirect ELISA: suitable microarray: suitable western blot: 0.25-0.5 μg/mL using total cell extracts from NIH3T3 cells |
| isotype【同位素/亚型】 | IgG2b |
| UniProt accession no.【UniProt登记号】 | Q92769 |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... HDAC2(3066) mouse ... Hdac2(15182) rat ... Hdac2(84577) |
| packaging【包装】 | 200 μL in glass insert |
产品说明
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 2 |
| Personal Protective Equipment【个人防护装备】 | Eyeshields, Gloves, multi-purpose combination respirator cartridge (US) |
