Anti-IRF7 (ab1) antibody produced in rabbit

MFCD02096777

NA.41

Interferon regulatory factor 7 (IRF7) protein, a multifunctional transcription factor, is a lymphoid-specific factor expressed in the cytoplasm in B cells, plasmacytoid dendritic cells (pDCs), and monocytes in the spleen, thymus, and peripheral blood lymphocytes. IRF7 gene is located on human chromosome 11p15.5.

a peptide corresponding to 14 amino acids near the carboxy-terminus of human IRF7 .

Anti-IRF7 (ab1) antibody produced in rabbit has been used in immunoblotting.

Interferon regulatory factor 7 (IRF7) protein plays a key role in regulating the type I interferon (IFN) alpha/beta (IFNα/β) responses, which are necessary to innate and adaptive immunity. Hence IRF7 is considered as the ‘master′ controller of IFN type I production. It plays a key role in priming. IRF7 can also form homodimers or heterodimers with interferon regulatory factor 5 (IRF5) to modulate target genes. It might regulate oncogenesis and apoptosis. IRF7 plays an important role in the pathogenesis of type I diabetes. It is connected to the latency of the Epstein–Barr virus (EBV).

The action of this antibody can be blocked using blocking peptide SBP3941.

Solution in phosphate buffered saline containing 0.02% sodium azide

rabbit

100

unconjugated

affinity isolated antibody

primary antibodies

polyclonal

buffered aqueous solution

human, rat, mouse

immunofluorescence: suitable
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable

Q92985

dry ice

−20℃

human ... IRF7(3665)

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12 - Non Combustible Liquids

WGK 2