(±)-巴氯芬

C₁₀H₁₂ClNO₂

213.66

214-486-9

MFCD00055143

24278146

NA.32

(±)-Baclofen has been used as γ-aminobutyric acid receptor B GABA_B receptor agonist:

• as well as control GABAergic drug to test its protective effects on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic toxicity
• to test its effects on in vivo motor function tests and performance of mutant mice
• to test its excitability effect on dopaminergic (DA) neurons of the ventral tegmental area (VTA)
• to test its effect in reducing dendritic excitability in Purkinje neurons

Baclofen, a γ-aminobutyric acid (GABA) analog, possesses myorelaxant properties Being a γ-aminobutyric acid receptor B (GABA_B) agonist, baclofen may be involved in the potentiation of dendritic potassium K⁺ channels. It may be useful in blocking transient lower esophageal sphincter relaxation (TLESR) in gastroesophageal reflux disease (GERD). Baclofen may also have scope for treating addictive especially, in alcohol use disorder (AUD).
GABA _B 受体激动剂；骨骼肌松弛剂；解痉剂。

100

≥98% (TLC)

solid

white to very faintly yellow

1 M HCl: 50 mg/mL

2-8℃

ClC1=CC=C(C(CN)CC(O)=O)C=C1

1S/C10H12ClNO2/c11-9-3-1-7(2-4-9)8(6-12)5-10(13)14/h1-4,8H,5-6,12H2,(H,13,14)

KPYSYYIEGFHWSV-UHFFFAOYSA-N

human ... GABBR1(2550), GABBR2(9568)
rat ... Gabbr1(81657), Gabra2(29706)

GHS06

Danger

H301

P264 - P270 - P301 + P310 - P405 - P501

Acute Tox. 3 Oral

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK 3

Eyeshields, Faceshields, Gloves, type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges