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ANTI-LC3 (APG8B) (C-TERM) antibody produced in rabbit
| 产品编号： | 3372979 |
| 规格： | purified immunoglobulin, buffered aqueous solution |
| 包装规格： | 400 μL |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
ANTI-LC3 (APG8B) (C-TERM) antibody produced in rabbit
Autophagy-related protein LC3 B
Microtubule-associated proteins 1A/1B light chain 3B
MAP1LC3B
Autophagy-related ubiquitin-like modifier LC3 B
MAP1ALC3
基本信息
| NACRES | NA.41 |
| General description【一般描述】 | LC3B or MAP1LC3B (microtubule associated protein 1 light chain 3 β) is a homolog of the ATG8 gene, which is an autophagy-related gene in yeast. The encoded protein is called pro-MAP1LC3B, a pro-form that is cleaved by ATG4 to produce a cytosolic form called MAP1LC3B-I. |
| Biochem/physiol Actions【生化/生理作用】 | MAP1LC3B-I (microtubule associated protein 1 light chain 3 β-I) associates with MAP1LC3B-II before being inserted into the inner and outer membranes of the growing autophagic vesicle during autophagy. The cellular distribution and processing of MAP1LC3B facilitates monitoring of autophagy. Cells that lack MAP1LC3B are found to be defective in the formation of autophagic vesicles, with altered phenotypes associated with the role of autophagy in energy homeostasis and removal of protein aggregates. MAP1LC3B can serve as an autophagic marker. |
| Physical form【外形】 | Supplied in PBS with 0.09% (W/V) sodium azide |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| antibody form【抗体形式】 | purified immunoglobulin |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| form【形式】 | buffered aqueous solution |
| mol wt【分子量】 | 14688 Da |
| species reactivity | human |
| technique(s) | immunohistochemistry: 1:50-1:100 western blot: 1:1000 |
| NCBI accession no.【NCBI登记号】 | NP_073729.1 |
| UniProt accession no.【UniProt登记号】 | Q9GZQ8 |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... MAP1LC3B(81631) |
产品说明
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
