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Anti-Leukemia Inhibitory Factor antibody produced in goat
| 产品编号： | 3373238 |
| 规格： | IgG fraction of antiserum, lyophilized powder |
| 包装规格： | 1 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-Leukemia Inhibitory Factor antibody produced in goat
Anti-LIF
基本信息
| MDL number | MFCD00212999 |
| NACRES | NA.41 |
| General description【一般描述】 | Leukemia inhibitory factor (LIF) is a pleotrophic glycoprotein that belongs to the IL6 family of cytokines. It is secreted by many cell types such as, fibroblasts, macrophages, T cells, monocytes, liver cells, osteoblasts and cells of endometrium. LIF interacts with a heterodimeric receptor composed of two subunits, gp130 and gp190. A variety of signal transduction pathways are triggered in response to LIF including ERK/MAPK, JAK1, PI3K, STAT3, Jun-cFos and NF-κB. The various functions of LIF include proliferation of adult human T cells, maintenance of pluripotency of embryonic stem cells and inhibition of leukemic ell differentiation. Reports also indicate the important role of LIF in lactation, tissue regeneration after brain and spinal cord injury, muscle regeneration and motor neuron functions. Anti-Leukemia Inhibitory Factor recognizes human leukemia inhibitory factor. It shows no cross-reactivity with recombinant mouse LIF. |
| Specificity【特异性】 | The antibody neutralizes the biological activity of recombinant human LIF. |
| Immunogen【免疫原】 | recombinant human LIF expressed in E. coli |
| Application【应用】 | Anti-Leukemia Inhibitory Factor antibody may be for immunoblotting a concentration of 1 μg/ml For ELISA a working concentration of 1 μg/ml is recommended. The antibody is suitable for neutralization reactions. For neutralization of LIF in SEK1, melanoma cell line, a concentration of 100 μg/ml was used. |
| Physical form【外形】 | Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline |
| Preparation Note【制备说明】 | Purified using protein G |
产品性质
| Quality Level【质量水平】 | 100 |
| biological source【生物来源】 | goat |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | IgG fraction of antiserum |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| form【形式】 | lyophilized powder |
| species reactivity | human |
| technique(s) | neutralization: suitable |
| UniProt accession no.【UniProt登记号】 | P15018 |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... LIF(3976) |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
| Personal Protective Equipment【个人防护装备】 | Eyeshields, Gloves, type N95 (US) |
