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Anti-MAP2K4 antibody produced in rabbit
产品别名
Anti-MAP2K4 antibody produced in rabbit
Anti-PRKMK4
Anti-MKK4
Anti-SERK1
Anti-MEK4
Anti-JNKK1
基本信息
| NACRES | NA.41 |
| General description【一般描述】 | The antibody detects endogenous levels of total MAP2K4 protein. |
| Immunogen【免疫原】 | Peptide sequence around aa. 352-356 (E-S-K-R-P), according to the protein NP_003001.1 |
| Features and Benefits【特点和优势】 | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| Physical form【外形】 | Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol |
产品性质
| biological source【生物来源】 | rabbit |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| form【形式】 | buffered aqueous solution |
| mol wt【分子量】 | ~44 kDa |
| species reactivity | mouse, human, rat |
| concentration【浓度】 | 1 mg/mL |
| technique(s) | western blot: 1:500-1:1000 |
| isotype【同位素/亚型】 | IgG |
| immunogen sequence【免疫原序列】 | (E-S-K-R-P) |
| NCBI accession no.【NCBI登记号】 | NM_003010.2 |
| UniProt accession no.【UniProt登记号】 | P45985 |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... MAP2K4(6416) |
产品说明
| Target description【目标描述】 | SAPK/Erk kinase (SEK1), also known as MKK4 or Jun kinase kinase (JNKK), activates the MAP kinase homologues SAPK and JNK in response to various cellular stresses and inflamatory cytokines (1-3). Activation of SEK1 occurs through MEKK phosphorylation of serine and threonine residues at positions 257 and 261, respectively. Like MEK, SEK is a dual-specificity protein kinase that phosphorylates SAPK/JNK at a conserved T*PY* site in its activation loop (4). Phosphorylation by Akt at Ser80 inhibits SEK1 and suppresses stress-activated signal transduction (5). |
安全信息
| Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
| WGK | WGK 1 |
