Anti-MSH3 (center) antibody produced in rabbit

NA.41

MSH3 is a component of the post-replicative DNA mismatch repair system (MMR). THis protein heterodimerizes with MSH2 to form MutS beta which binds to DNA mismatches thereby initiating DNA repair. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. MutS beta recognizes large insertion-deletion loops (IDL) up to 13 nucleotides long. After mismatch binding, it forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis.

MSH3 (NP_002430, 464-497)
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the Center region of human MSH3.

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

rabbit

100

unconjugated

saturated ammonium sulfate (SAS) precipitated

primary antibodies

polyclonal

buffered aqueous solution

human

indirect ELISA: 1:1000
western blot: 1:100-1:500

NP_002430

P20585

dry ice

−20℃

human ... MSH3(4437)

12 - Non Combustible Liquids

nwg