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Anti-MST3 (C-term) antibody produced in rabbit
| 产品编号： | 3378413 |
| 规格： | IgG fraction of antiserum, buffered aqueous solution |
| 包装规格： | 100 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-MST3 (C-term) antibody produced in rabbit
Anti-STE20-like kinase MST3
Anti-Serine/threonine protein kinase 24
Anti-Mammalian STE20-like protein kinase 3
Anti-STK3
Anti-STK24
基本信息
| NACRES | NA.41 |
| General description【一般描述】 | The yeast ‘Sterile 20′ gene (STE20) functions upstream of the mitogen-activated protein kinase (MAPK) cascade. In mammals, protein kinases related to STE20 can be divided into 2 subfamilies based on their structure and regulation. Members of the PAK subfamily (see PAK3; MIM 300142) contain a C-terminal catalytic domain and an N-terminal regulatory domain that has a CDC42 (MIM 116952)-binding domain. In contrast, members of the GCK subfamily (see MAP4K2; MIM 603166), also called the Sps1 subfamily, have an N-terminal catalytic domain and a C-terminal regulatory domain without a CDC42-binding domain. STK24 belongs to the GCK subfamily of STE20-like kinases (Zhou et al., 2000 [PubMed 10644707]).[supplied by OMIM] MST3 (mammalian sterile 20 (Ste20)-like kinase 3) gene is mapped to human chromosome 13q32.2. The gene is ubiquitously expressed in different tissues. MST3 belongs to the subfamily of the germinal centre kinase III kinases. It is also known as serine/threonine kinase 24 (STK24). The encoded protein contains a kinase domain and a regulatory domain at the N and C-terminal, respectively. The protein includes two isoforms namely MST3a and MST3b which differ by 12 amino acids. The protein is mostly localized in the cytoplasm. |
| Immunogen【免疫原】 | MST3 (Q9Y6E0, 350-384) This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human MST3. |
| Biochem/physiol Actions【生化/生理作用】 | MST3 (mammalian sterile 20 (Ste20)-like kinase 3) is known to be involved in the development of proper filopodia, dendritic spine, and excitatory synapse. MST3 induces outgrowth of axon and its regeneration in vivo. MST3 is associated with Caspase 3-mediated apoptosis in trophoblasts, induced by hypoxia. |
| Physical form【外形】 | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | IgG fraction of antiserum |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| form【形式】 | buffered aqueous solution |
| species reactivity | human |
| technique(s) | immunohistochemistry: 1:50-1:100 indirect ELISA: 1:1000 western blot: 1:100-1:500 |
| NCBI accession no.【NCBI登记号】 | NP_003567 |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... MST3(8428) |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | nwg |
