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Anti-Munc-18-3 兔抗
Anti-Munc-18-3 antibody produced in rabbit
| 产品编号： | 3378758 |
| 规格： | affinity isolated antibody, buffered aqueous solution |
| 包装规格： | 200 μL |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-Munc-18-3 兔抗
Anti-Munc-18-3 antibody produced in rabbit
Anti-PSP
Anti-UNC-18C
Anti-Syntaxin Binding Protein 3 (STXBP3)
Anti-MUNC18C
基本信息
| NACRES | NA.41 |
| General description【一般描述】 | Mammalian uncoordinated-18-3 (Munc-18-3) (also known as Munc-18c, syntaxin-binding protein 3, STXBP3) is ubiquitously expressed. |
| Immunogen【免疫原】 | synthetic peptide corresponding to amino acids 578-592 located at the C-terminus of mouse Munc-18-3, conjugated to KLH. This sequence is highly conserved (~90% identity) in human and rat Munc-18-3. |
| Application【应用】 | Anti-Munc-18-3 antibody produced in rabbit has been used in immunohistochemistry and western blotting |
| Biochem/physiol Actions【生化/生理作用】 | Mammalian uncoordinated-18-3 (Munc-18-3) expressed in 3T3-L1 adipocytes has been shown to interact with syntaxin 2 and 4 and to inhibit the binding of syntaxin-4 to vesicle associated membrane protein 2 (VAMP2). Munc-18c has been suggested to play a role in the docking/fusion of glucose transporter type 4 (GLUT4)-containing vesicles with the cell membrane of 3T3-L1 adipocytes. Heterozygous knock-out of the Munc-18c gene in mice impairs insulin-stimulated GLUT4 translocation in skeletal muscle and increases the susceptibility for severe glucose intolerance. Munc-18-3 has a role in glucose metabolism and is involved in controlling the translocation of glucose transporter type 4 (GLUT4) in adipocytes. |
| Physical form【外形】 | 0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。 |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 200 |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| form【形式】 | buffered aqueous solution |
| mol wt【分子量】 | antigen ~66 kDa |
| species reactivity | human, rat, mouse |
| technique(s) | western blot: 0.75-1.5 μg/mL using mouse brain extract (S1 fraction) |
| UniProt accession no.【UniProt登记号】 | O00186 |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... STXBP3(6814) mouse ... Stxbp3a(20912) rat ... Stxbp3(114095) |
产品说明
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | nwg |
