Anti-N-RAS antibody, Rabbit monoclonal

NA.41

GTPase N-Ras or N-Ras is a guanine-nucleotide binding protein. Receptor tyrosine kinases and G-protein-coupled receptors activate Ras, which then stimulates the MAPK signal pathway. Point mutations (Q61R) in Ras prevent the GAP-mediated inhibition of the MAPK pathway in certain cancers such as lung carcinoma and melanoma. Abnormal MAPK signaling may lead to uncontrolled cell proliferation, resistance to both apoptosis and cancer therapy.

Synthetic peptide of human N-Ras protein containing N-Ras (Q61R) point mutation.

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0.1 ml rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.

rabbit

100

expressed in proprietary host

unconjugated

affinity isolated antibody

primary antibodies

SP174, monoclonal

human (tested)

immunoblotting: 1:400
immunohistochemistry: 1:100

IgG

P01111

wet ice

2-8℃

human ... NRAS(4893)

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12 - Non Combustible Liquids

WGK 2