Anti-NDE1 antibody produced in rabbit

NA.41

NDE1 codes for a protein that belongs to the nuclear distribution E (NudE) family. It forms a part of a multiprotein complex that modulates the function of dynein. Phoshorylated NDE1 is known to interact with NDEL1 and LIS1. NDE1 represses ciliogenesis and modulates cell cycle re-entry. Mutations in NDE1 have been linked to microcephaly with lissencephaly.
Rabbit Anti-NDE1 antibody recognizes chicken, human, mouse, rat, rabbit, zebrafish, bovine, and canine NDE1.

Synthetic peptide directed towards the middle region of human NDE1

Rabbit Anti-NDE1 antibody is suitable for western blot applications at a concentration of 1μg/ml.

NDE1 is required for centrosome duplication and formation and function of the mitotic spindle. It is essential for the development of the cerebral cortex. NDE1 may regulate the production of neurons by controlling the orientation of the mitotic spindle during division of cortical neuronal progenitors of the proliferative ventricular zone of the brain. Orientation of the division plane perpendicular to the layers of the cortex gives rise to two proliferative neuronal progenitors whereas parallel orientation of the division plane yields one proliferative neuronal progenitor and a post-mitotic neuron. A premature shift towards a neuronal fate within the progenitor population may result in an overall reduction in the final number of neurons and an increase in the number of neurons in the deeper layers of the cortex

Synthetic peptide located within the following region: AHRGPSSSLNTPGSFRRGLDDSTGGTPLTPAARISALNIVGDLLRKVGAL

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

rabbit

100

unconjugated

affinity isolated antibody

primary antibodies

polyclonal

buffered aqueous solution

38 kDa

rabbit, guinea pig, human, dog, mouse, bovine, horse, rat

0.5 mg - 1 mg/mL

western blot: suitable

NP_001137451

Q9NXR1-2

wet ice

−20℃

human ... NDE1(54820)

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12 - Non Combustible Liquids

WGK 3