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Anti-p15 INK antibody produced in rabbit
产品别名
Anti-p15 INK antibody produced in rabbit
MTS2
Multiple tumor suppressor 2
CDN2B
CDKN2B
Cyclin-dependent kinase 4 inhibitor B
基本信息
| NACRES | NA.41 |
| General description【一般描述】 | Anti-p15 INK Antibody detects endogenous levels of total p15 INK protein. Cyclin-dependent kinase inhibitor 2B (CDKN2B) gene codes for tumor-suppressor p15INK4B protein. p15INK4B is a member of the INK4 family of protein kinase inhibitors. In bone marrow cells, p15INK4B expression is mainly seen at a high level in maturing monocytes/macrophages and lymphocytes. It is located in the nucleus and cytoplasm. The CDKN2B gene is mapped to human chromosome 9p21.3. Anti-p15 INK Antibody detects endogenous levels of total p15 INK protein. |
| Immunogen【免疫原】 | The antiserum was produced against synthesized peptide derived from human p15 INK. Immunogen Range: 89-138 |
| Application【应用】 | Anti-p15 INK antibody produced in rabbit has been used in western blot (1:500). |
| Biochem/physiol Actions【生化/生理作用】 | Cyclin-dependent kinase inhibitor 2B (CDKN2B) plays a key role in the cell cycle and senescence. It participates in the differentiation of the hematopoietic cell. CDKN2B gene is involved in the pathogenesis of T-acute lymphoblastic leukemia (T-ALL). Homozygous deletion of the CDKN2B gene or p15INK4B locus on chromosome results in glioblastoma multiforme (GBM). Silencing of p15INK4B is associated with myelodysplastic syndromes, leukemia, and myeloproliferative diseases. |
| Features and Benefits【特点和优势】 | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| Physical form【外形】 | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
产品性质
| biological source【生物来源】 | rabbit |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| form【形式】 | buffered aqueous solution |
| mol wt【分子量】 | antigen 14 kDa |
| species reactivity | mouse, rat, human |
| concentration【浓度】 | ~1 mg/mL |
| technique(s) | ELISA: 1:5000 immunofluorescence: 1:100-1:500 immunohistochemistry: 1:50-1:100 western blot: 1:500-1:1000 |
| NCBI accession no.【NCBI登记号】 | P42772 |
| UniProt accession no.【UniProt登记号】 | P42772 |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... CDKN2B(1030) |
产品说明
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | nwg |
