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Anti-p35 (Cdk5 Regulator) antibody produced in rabbit
| 产品编号： | 3382029 |
| 规格： | IgG fraction of antiserum, buffered aqueous solution |
| 包装规格： | 0.2 ML |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
基本信息
| MDL number | MFCD00211612 |
| NACRES | NA.46 |
| General description【一般描述】 | Cell division protein kinase 5 (Cdk5) is a serine/threonine kinase and shares homology to other Cdks. It belongs to cdk family. |
| Immunogen【免疫原】 | synthetic peptide corresponding to the C-terminus of p35 (Cdk5R), (human, amino acids 192-209). |
| Application【应用】 | Anti-p35 (Cdk5 Regulator) antibody produced in rabbit has been used in western blotting and immunohistochemistry. |
| Biochem/physiol Actions【生化/生理作用】 | Cell division protein kinase 5 (Cdk5) kinase activity can be detected mainly in postmitotic neurons in the central nervous system (CNS). Cdk5/p35 activity is required in the mature CNS. Cdk5 phosphorylates dopamine and cyclic adenosine 3′,5′-monophosphate-regulated phosphoprotein of 32 kDa (DARPP-32) and Syntaxin-binding protein 1 (Munc18), which in turn affects synaptic vesicle endocytosis. Deregulation of Cdk5 activity contributes to the pathogenesis of neurodegenerative diseases such as Alzheimer′s disease (AD). It mediates neuronal migration during cortical development. Cdk5-/- mice exhibit embryonic lethality associated with disruption of the cortical laminar structures in the cerebral cortex, olfactory bulb, hippocampus, and cerebellar cortex. Mice lacking p35 display defects in cortical lamination and fasciculation of axonal fibers. In developing mice brain, Cdk5/p35 interacts with Reelin/Dab1 and positions of cortical neurons. |
| Physical form【外形】 | 0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。 |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 200 |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | IgG fraction of antiserum |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| form【形式】 | buffered aqueous solution |
| mol wt【分子量】 | antigen 35 kDa |
| species reactivity | human, rat |
| technique(s) | microarray: suitable western blot: 1:1,000 using a rat brain extract (cytosolic fraction) |
| UniProt accession no.【UniProt登记号】 | Q15078 |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... CDK5R1(8851) rat ... Cdk5r1(116671) |
产品说明
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
