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Anti-p57Kip2 antibody produced in rabbit
| 产品编号： | 3382107 |
| 规格： | IgG fraction of antiserum, buffered aqueous solution |
| 包装规格： | 200 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-p57Kip2 antibody produced in rabbit
Anti-Kip2
基本信息
| MDL number | MFCD01633561 |
| NACRES | NA.41 |
| General description【一般描述】 | Cyclin-dependent kinase inhibitor p57 (CDKN1C) or p57KIP2 (kinase inhibitory protein) is a tumor suppressor gene. It is a 316 amino acid protein with conserved amino- and carboxy-terminal domains and sequences with proline-alanine repeats. During mouse embryogenesis, p57KIP2 transcript is highly expressed in skeletal muscles, brain, heart, lungs and eye. The gene encoding this protein is localized on human chromosome 11p15.4. |
| Immunogen【免疫原】 | synthetic peptide corresponding to amino acids 303-316 of human Kip2, conjugated to KLH. |
| Application【应用】 | Anti-p57Kip2 antibody produced in rabbit has been used in Western blotting. |
| Biochem/physiol Actions【生化/生理作用】 | Cyclin-dependent kinase inhibitor p57 (CDKN1C) or p57KIP2 (kinase inhibitory protein) plays a vital role as a tight-binding inhibitor of several G1 cyclin/cyclin-dependent kinase (CDK) complexes. It is a negative regulator of cell proliferation. Mutation in this gene has been associated with Beckwith-Wiedemann syndrome. p57Kip2 facilitates direct inhibition of DNA replication by binding to the proliferating cell nuclear antigen. |
| Physical form【外形】 | Solution in 0.1 M Tris-glycine, pH 7.4, containing 0.15 M NaCl, and 0.05% sodium azide. |
| Preparation Note【制备说明】 | Purified using protein A |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 200 |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | IgG fraction of antiserum |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| form【形式】 | buffered aqueous solution |
| mol wt【分子量】 | antigen 57 kDa |
| species reactivity | human, mouse (predicted), bovine |
| technique(s) | immunoprecipitation (IP): 5 μg using 0.5-1 mg of HeLa nuclear extract and a bovine brain nuclear extract western blot: 2 μg/mL using HeLa nuclear extract and bovine brain nuclear extract |
| UniProt accession no.【UniProt登记号】 | P49918 |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... CDKN1C(1028) mouse ... Cdkn1c(12577) |
产品说明
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
