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Anti-Paraoxonase 1 (PON1) 兔抗
Anti-Paraoxonase 1 (PON1) antibody produced in rabbit
| 产品编号： | 3382443 |
| 规格： | ~1 mg/mL, affinity isolated antibody, buffered aqueous solution |
| 包装规格： | 200 μL，100 μL |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-Paraoxonase 1 (PON1) 兔抗
Anti-Paraoxonase 1 (PON1) antibody produced in rabbit
Anti-Arylesterase
Anti-PON1
Anti-Coronary Artey Disease, Susceptibility to
Anti-Organophosphate Poisoning, Sensitivity to
Anti-Coronary Spasms, Susceptibility to
Anti-Parathion Poisoning, Sensitivity to
Anti-Esterase A (ESA)
基本信息
| MDL number | MFCD09265365 |
| NACRES | NA.41 |
| General description【一般描述】 | Paraoxonase-1 (PON1) is a member of serum paraoxonases family, consisting of PON1, PON2, and PON3. Human PONs map to the long arm of chromosome 7. PON1 is polymorphic in human populations, and different individuals express widely different levels of this enzyme. PON1 and PON3 are expressed in the liver and secreted into the blood where they are associated with the high-density lipoprotein (HDL) particle. |
| Immunogen【免疫原】 | synthetic peptide corresponding to amino acids 298-309 of human PON1, conjugated to KLH via an N-terminal cysteine residue. The corresponding sequence differs by one amino acid in mouse and two amino acids in rat. The peptide sequence differs by one amino acid in human PON2 and two amino acids in human PON3. |
| Application【应用】 | Anti-Paraoxonase 1 (PON1) antibody produced in rabbit has been used in immunoblotting, and immunofluorescence . |
| Biochem/physiol Actions【生化/生理作用】 | Paraoxonase-1 (PON1) protects lipids from oxidation in lipoproteins, macrophages, and erythrocytes. PON1 may confer protection against coronary artery disease by destroying proinflammatory oxidized lipids present in oxidized low-density lipoproteins (LDLs). PON1 plays a key role in the detoxification of organophosphate insecticides such as parathion, chlorpyrifos and diazinon and nerve gases such as soman and sarin. |
| Physical form【外形】 | Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide. |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 200 |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| form【形式】 | buffered aqueous solution |
| mol wt【分子量】 | antigen ~40 kDa |
| species reactivity | mouse (predicted), human, rat (predicted) |
| concentration【浓度】 | ~1 mg/mL |
| technique(s) | indirect immunofluorescence: 5-10 μg/mL using human HT-29 cells western blot: 0.5-1 μg/mL using whole extract of human colorectal adenocarcinoma HT-29 cells |
| UniProt accession no.【UniProt登记号】 | P27169 |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... PON1(5444) mouse ... Pon1(18979) rat ... Pon1(84024) |
产品说明
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 3 |
| Personal Protective Equipment【个人防护装备】 | Eyeshields, Gloves, multi-purpose combination respirator cartridge (US) |
