您的位置：首页 > 产品中心 > Anti-PCAF antibody produced in rabbit
Anti-PCAF antibody produced in rabbit
产品别名
Anti-PCAF antibody produced in rabbit
Anti-p300/CBP-associated factor
基本信息
| MDL number | MFCD03791929 |
| NACRES | NA.41 |
| General description【一般描述】 | PCAF is a histone acetylase that functions as a nuclear receptor coactivator. Studies have reported that PCAF acetylates p53 sites in vitro. Rabbit Anti-PCAF antibody recognizes rat, bovine, chicken, zebrafish, canine, mouse, and human PCAF. |
| Immunogen【免疫原】 | Synthetic peptide directed towards the N terminal region of human PCAF |
| Application【应用】 | Rabbit Anti-PCAF antibody can be used for western blot applications at a concentration of 2.5μg/ml. |
| Biochem/physiol Actions【生化/生理作用】 | CBP and p300 are large nuclear proteins that bind to many sequence-specific factors involved in cell growth and/or differentiation, including c-jun and the adenoviral oncoprotein E1A. PCAF associates with p300/CBP. It has in vitro and in vivo binding activity with CBP and p300, and competes with E1A for binding sites in p300/CBP. It has histone acetyl transferase activity with core histones and nucleosome core particles, indicating that this protein plays a direct role in transcriptional regulation.CBP and p300 are large nuclear proteins that bind to many sequence-specific factors involved in cell growth and/or differentiation, including c-jun and the adenoviral oncoprotein E1A. The protein encoded by this gene associates with p300/CBP. It has in vitro and in vivo binding activity with CBP and p300, and competes with E1A for binding sites in p300/CBP. It has histone acetyl transferase activity with core histones and nucleosome core particles, indicating that this protein plays a direct role in transcriptional regulation. |
| Sequence【序列】 | Synthetic peptide located within the following region: LFKLLRKSILQRGKPVVEGSLEKKPPFEKPSIEQGVNNFVQYKFSHLPAK |
| Physical form【外形】 | Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | IgG fraction of antiserum |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| form【形式】 | buffered aqueous solution |
| mol wt【分子量】 | 93 kDa |
| species reactivity | human, dog, guinea pig, rat, mouse, horse, bovine, rabbit |
| concentration【浓度】 | 0.5 mg - 1 mg/mL |
| technique(s) | western blot: suitable |
| NCBI accession no.【NCBI登记号】 | NP_003875 |
| UniProt accession no.【UniProt登记号】 | Q92831 |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... PCAF(8850) |
产品说明
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 3 |
