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Anti-phospho-BRCA1 (pSer1423) antibody produced in rabbit
产品别名
Anti-phospho-BRCA1 (pSer1423) antibody produced in rabbit
Anti-breast cancer 1, early onset antibody produced in rabbit
Anti-IRIS antibody produced in rabbit
Anti-BRCAI antibody produced in rabbit
Anti-PSCP antibody produced in rabbit
Anti-BRCC1 antibody produced in rabbit
基本信息
| MDL number | MFCD01092286 |
| NACRES | NA.41 |
| Immunogen【免疫原】 | Peptide sequence around phosphorylation site of serine 1423 (H-G-S(p)-Q-P), according to the protein BRCA1. |
| Features and Benefits【特点和优势】 | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| Physical form【外形】 | Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol |
产品性质
| biological source【生物来源】 | rabbit |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| form【形式】 | buffered aqueous solution |
| mol wt【分子量】 | ~220 kDa |
| species reactivity | human |
| concentration【浓度】 | 1 mg/mL |
| technique(s) | immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100 western blot: 1:500-1:1000 |
| isotype【同位素/亚型】 | IgG |
| immunogen sequence【免疫原序列】 | (H-G-SP-Q-P) |
| NCBI accession no.【NCBI登记号】 | NP_009225.1 |
| UniProt accession no.【UniProt登记号】 | P38398 |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... BRCA1(672) |
产品说明
| Target description【目标描述】 | The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Plays a central role in DNA repair by facilitating cellular response to DNA repair. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for FANCD2 targeting to sites of DNA damage. May function as a transcriptional regulator. Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
| WGK | WGK 1 |
