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Anti-phospho-FAK (pTyr397) antibody produced in rabbit
基本信息
| NACRES | NA.41 |
| General description【一般描述】 | Protein tyrosine kinase 2 (PTK2), also known as FAK (focal adhesion kinase), is encoded by the gene mapped to human chromosome 8q24-qter. The encoded protein is localized to cell adhesion sites and extracellular matrix. |
| Immunogen【免疫原】 | The antiserum was produced against synthesized peptide derived from human FAK around the phosphorylation site of Tyr397. Immunogen Range: 364-413 |
| Biochem/physiol Actions【生化/生理作用】 | Protein tyrosine kinase 2 (PTK2) is a non-receptor tyrosine kinase which is known to regulate cell migration, proliferation, cell survival and invasiveness. Increased expression of FAK (focal adhesion kinase) leads to metastatic breast tumors and lung cancer. Inhibition of FAK tyrosine kinase activity stops various cellular process necessary for tumor growth. Hence, FAK inhibitors are considered to be potential therapeutic methods for cancer treatment. FAK is one of the important components of integrin adhesion complexes (IACs)and it plays a vital role in maintaining IAC dynamics. Cell interactions with components of extracellular matrix and a number of agonists, such as neuropeptides, activate Ptk2. Ptk2, mediates cell signaling through its kinase dependent/independent functions. Upregulation of the gene is observed in hepatocellular carcinoma, which is accompanied with portal venous invasion and intrahepatic metastasis. |
| Features and Benefits【特点和优势】 | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| Physical form【外形】 | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| form【形式】 | buffered aqueous solution |
| mol wt【分子量】 | antigen 119 kDa |
| species reactivity | rat, human, mouse |
| concentration【浓度】 | ~1 mg/mL |
| technique(s) | ELISA: 1:5000 western blot: 1:500-1:1000 |
| NCBI accession no.【NCBI登记号】 | Q05397 |
| UniProt accession no.【UniProt登记号】 | Q05397 |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... PTK2(5747) |
产品说明
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
