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Anti-phospho-Myristoylated Alanine-Rich Protein Kinase C Substrate (pSer152/156) antibody produced in rabbit
| 产品编号： | 3385245 |
| 规格： | affinity isolated antibody, buffered aqueous glycerol solution |
| 包装规格： | 100 μL |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-phospho-Myristoylated Alanine-Rich Protein Kinase C Substrate (pSer152/156) antibody produced in rabbit
Anti-phospho-MARCKS (pSer152/156)
基本信息
| MDL number | MFCD03792006 |
| NACRES | NA.44 |
| General description【一般描述】 | The proteins of myristoylated alanine-rich C kinase substrate (MARCKS) family are identified as the ubiquitous substrates of Protein Kinase C (PKC). There are two identified members of MARCKS family, a 32 kDa ubiquitously expressed protein and a 20 kDa protein that is expressed in brain, macrophages and reproductive tissues. MARCKS proteins have vital role to play in the development of brain, cellular migration and adhesion, phagocytosis, neurosecretion and postnatal survival. MARCKS is also a key regulator in the mucin granule release and thereby secretion of mucus in airway. The phosphorylation domain of MARCKS protein contains the serine residues (serine 152, 156 and 163) that are activated by PKC. Besides PKC, MARCKS is also a target for calcium-calmodulin (CaM) and is reported as the potential protein that mediates a crosstalk between CaM and PKC. MARCKS participates in regulation of cytoskeleton by binding with actin and cell membrane Anti-phospho-MARCKS (pSer152/156) specifically recognizes MARCKS (80 kDa) phosphorylated at serine 152/156. |
| Immunogen【免疫原】 | synthetic phosphorylated peptide derived from the region of rat MARCKS, which is phosphorylated on serine 152/156. |
| Application【应用】 | A working dilution of 1:1000 is recommended for detection of MARCKS, phosphorylated at Ser152/156, by immunoblotting in rat hippocampal tissue homogenates. |
| Physical form【外形】 | Solution in 10 mM HEPES, pH 7.5, containing 150 mM NaCl, 100 μg/ml BSA and 50% glycerol. |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 200 |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| form【形式】 | buffered aqueous glycerol solution |
| mol wt【分子量】 | antigen 80 kDa |
| species reactivity | mouse, rat, human |
| technique(s) | western blot: 1:1000 |
| UniProt accession no.【UniProt登记号】 | P29966 |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... MARCKS(4082) mouse ... Marcks(17118) rat ... Marcks(25603) |
产品说明
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
