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Anti-phospho-PTK2B (pTyr402) antibody produced in rabbit
产品别名
Anti-phospho-PTK2B (pTyr402) antibody produced in rabbit
Anti-FAK2 antibody produced in rabbit
Anti-FADK2 antibody produced in rabbit
Anti-PTK2B protein tyrosine kinase 2 beta antibody produced in rabbit
Anti-CADTK antibody produced in rabbit
Anti-CAKB antibody produced in rabbit
基本信息
| MDL number | MFCD01634069 |
| NACRES | NA.41 |
| General description【一般描述】 | Protein tyrosine kinase 2β (PTK2B) is a member of the focal adhesion kinase family which is expressed in the brain. The gene encoding it is localized on human chromosome 8. |
| Immunogen【免疫原】 | Peptide sequence around phosphorylation site of tyrosine 402 (D-I-Y(p)-A-E), according to the protein PTK2B. |
| Biochem/physiol Actions【生化/生理作用】 | Protein tyrosine kinase 2 β (PTK2B) takes part in the β2-mediated signaling pathway and activates mitogen activated protein kinase pathway. The protein has been shown to be upregulated in many tumors. PTK2B also has a role in cell proliferation and migration. It regulates ion channels which are induced by calcium. |
| Features and Benefits【特点和优势】 | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| Physical form【外形】 | Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| form【形式】 | buffered aqueous solution |
| mol wt【分子量】 | ~116 kDa |
| species reactivity | mouse, rat, human |
| concentration【浓度】 | 1 mg/mL |
| technique(s) | immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100 indirect immunofluorescence: 1:100-1:200 western blot: 1:500-1:1000 |
| isotype【同位素/亚型】 | IgG |
| immunogen sequence【免疫原序列】 | (D-I-YP-A-E) |
| NCBI accession no.【NCBI登记号】 | NP_004094.3 |
| UniProt accession no.【UniProt登记号】 | Q14289 |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... PTK2B(2185) |
产品说明
| Target description【目标描述】 | Involved in calcium induced regulation of ion channel and activation of the map kinase signaling pathway. May represent an important signaling intermediate between neuropeptide activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. Interacts with the SH2 domain of Grb2. May phosphorylate the voltage-gated potassium channel protein Kv1.2. Its activation is highly correlated with the stimulation of c-Jun N-terminal kinase activity. Involved in osmotic stress-dependent SNCA 'Tyr-125' phosphorylation. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
