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Anti-phospho-Src (pTyr529) antibody produced in rabbit
产品别名
Anti-phospho-Src (pTyr529) antibody produced in rabbit
Anti-ASV antibody produced in rabbit
Anti-v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) antibody produced in rabbit
Anti-p60-Src antibody produced in rabbit
Anti-c-SRC antibody produced in rabbit
Anti-SRC1 antibody produced in rabbit
基本信息
| MDL number | MFCD03455769 |
| NACRES | NA.41 |
| General description【一般描述】 | SRC proto-oncogene, non-receptor tyrosine kinase (SRC) belongs to the family of non-receptor tyrosine kinases.SRC contains an amino-terminal domain, conserved Src-homology domains (SH2 and SH3), a tyrosine kinase domain and the carboxyl-terminus.The gene encoding this protein is localized on human chromosome 20q11.23. |
| Immunogen【免疫原】 | Peptide sequence around phosphorylation site of tyrosine 529 (P-Q-Y(p)-Q-P), according to the protein SRC. |
| Biochem/physiol Actions【生化/生理作用】 | SRC proto-oncogene, non-receptor tyrosine kinase (SRC) phosphorylates membrane proteins and nucleoproteins and activates various intracellular signaling cascades. It is overexpressed and activated in a large number of human malignancies and has been linked to the development of cancer and progression to distant metastases. In addition to increasing cell proliferation, a key role of SRC in cancer seems to be the ability to promote invasion and motility, functions that might contribute to tumor progression. |
| Features and Benefits【特点和优势】 | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| Physical form【外形】 | Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| form【形式】 | buffered aqueous solution |
| mol wt【分子量】 | ~60 kDa |
| species reactivity | rat, human, mouse |
| concentration【浓度】 | 1 mg/mL |
| technique(s) | immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100 indirect immunofluorescence: 1:100-1:200 western blot: 1:500-1:1000 |
| isotype【同位素/亚型】 | IgG |
| immunogen sequence【免疫原序列】 | (P-Q-YP-Q-P) |
| NCBI accession no.【NCBI登记号】 | NP_005408.1 |
| UniProt accession no.【UniProt登记号】 | P12931 |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... SRC(6714) |
产品说明
| Target description【目标描述】 | proto-oncogenic cytoplasmic tyrosine kinase of the SRC family. Highly expressed in certain fully differentiated cells such as neurons, platelets and macrophages. Phosphorylation of an activation loop tyrosine activates the enzyme; phosphorylation of a tyrosine in the C-terminus by Csk inhibits the enzyme. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
| WGK | WGK 1 |
