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抗 PKM1 兔抗

Anti-PKM1 antibody produced in rabbit
产品编号:3386534
规格:affinity isolated antibody
包装规格:100 μG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
3386534100 μG7110
产品别名

抗 PKM1 兔抗

Anti-PKM1 antibody produced in rabbit

Anti-OIP3

Anti-PK2

Anti-PK3

Anti-PKM

基本信息
NACRES
NA.41
General description【一般描述】
PKM1 (pyruvate kinase M1/2) is an enzyme that belongs to the pyruvate kinase (PK) family. It is upregulated in majority of the cells other than adult muscle, brain and liver. PKM has two isoforms, M1 and M2, encoded by gene located on chromosome 15q23. PKM1 can exist as a tetramer whereas PKM2 can remain as dimer and tetramer.

The antibody detects endogenous levels of total PKM1 protein.
Immunogen【免疫原】
Peptide sequence around aa. 399-403 (V-R-A-S-S), according to the protein NP_872270.1
Biochem/physiol Actions【生化/生理作用】
Pyruvate kinase (PK) is an important enzyme in glycolysis as it helps to convert phosphoenolpyruvate (PEP) into pyruvate. Pyruvate kinase-M2 (PKM2) knockdown prevents the multiplication, movement and invasion in ovarian cancer SKOV3 and OVCAR3 cells. It plays an important role in cell survival to oxidative stress. It also participates in the development of tumor.
Features and Benefits【特点和优势】
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form【外形】
Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol
产品性质
biological source【生物来源】
rabbit
Quality Level【质量水平】
100
conjugate【偶联物】
unconjugated
antibody form【抗体形式】
affinity isolated antibody
antibody product type
primary antibodies
clone【克隆】
polyclonal
form【形式】
buffered aqueous solution
mol wt【分子量】
~60 kDa
species reactivity
mouse, human
concentration【浓度】
1 mg/mL
technique(s)
western blot: 1:500-1:1000
isotype【同位素/亚型】
IgG
immunogen sequence【免疫原序列】
(V-R-A-S-S)
NCBI accession no.【NCBI登记号】
NM_182470.1
shipped in【运输】
wet ice
storage temp.【储存温度】
−20℃
Gene Information
human ... PKM1(5315)
产品说明
Target description【目标描述】
Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio betwween the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival.
Disclaimer【免责声明】
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
安全信息
Storage Class Code【储存分类代码】
10 - Combustible liquids
WGK
WGK 1
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