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Anti-PM/Scl-100 antibody produced in rabbit
产品编号: | 3387006 |
规格: | ~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution |
包装规格: | 200 μL |
产品类别: | 进口试剂 |
品牌: | Sigma-Aldrich |
优惠价: | 立即咨询 |
产品别名
Anti-PM/Scl-100 antibody produced in rabbit
Anti-PMSCL2
Anti-Exsosome Component 10
Anti-PMSCL Autoantigen, 100-KD
Anti-Polymyositis/scleroderma autoantigen 2
Anti-Autoantigen PM/Scl 2
Anti-Polymyositis-scleroderma Overlap Syndrome Associated Autoantigen
Anti-Polymyositis/scleroderma Autoantigen, 100 kDa
Anti-EXOSC10
Anti-p100
基本信息
MDL number | MFCD08705502 |
NACRES | NA.41 |
General description【一般描述】 | PM/SCL-100 (human exosome) is also known as RRP6, EXOSC10 (exosome component 10). It is a heterogeneous autoantibody that is located on human chromosome 1p36. In mouse, EXOSC10 is located on XY body. |
Immunogen【免疫原】 | synthetic peptide corresponding to amino acid residues 231-245 of human PM/Scl-100 with an N-terminal added cysteine, conjugated to KLH. The corresponding sequence is identical in both rat and mouse PM/Scl-100. |
Application【应用】 | Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below. Immunofluorescence (1 paper) Western Blotting (1 paper) |
Biochem/physiol Actions【生化/生理作用】 | PM/SCL-100 (human exosome) participates in ribosome biogenesis, snoRNA (small nucleolar RNAs)processing, surveillance and degradation of nonfunctional transcripts. It is essential for the production of 40S subunit and to maintain global translation. EXOSC10 participates in mitotic cell division. In mouse, Exosc10 is required for spermatogonial proliferation and early embryogenesis. |
Physical form【外形】 | Solution in 0.01 M phosphate buffered saline, pH 7.4, and 15 mM sodium azide. |
产品性质
biological source【生物来源】 | rabbit |
Quality Level【质量水平】 | 200 |
conjugate【偶联物】 | unconjugated |
antibody form【抗体形式】 | affinity isolated antibody |
antibody product type | primary antibodies |
clone【克隆】 | polyclonal |
form【形式】 | buffered aqueous solution |
mol wt【分子量】 | antigen ~100 kDa |
species reactivity | mouse, human, rat |
concentration【浓度】 | ~1.0 mg/mL |
technique(s) | indirect immunofluorescence: 1-2 μg/mL using rat NRK and mouse NIH3T3 cells western blot (chemiluminescent): 1-2 μg/mL using nuclear exracts to HeLa human epithelioid carcinoma cells |
UniProt accession no.【UniProt登记号】 | Q01780 |
shipped in【运输】 | dry ice |
storage temp.【储存温度】 | −20℃ |
Gene Information | human ... EXOSC10(5394) mouse ... Exosc10(50912) |
产品说明
Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
WGK | WGK 3 |