Anti-Postn antibody produced in rabbit

NA.41

Periostin (POSTN) gene with 23 exons spanning 36 kb is mapped to chromosome 13q13.3. The gene codes for periostin, a matricellular protein that belongs to the family of non-structural matrix proteins. Periostin structure contains a signal peptide, four fasciclin-like domains (FAS1) with vitamin K-dependent γ-carboxyglutamic acid (Gla) residues, and hydrophilic C-terminal region with the heparin-binding site. The protein is mainly expressed in the periosteum, periodontal ligament, heart valves, and tendons. The antibody detects endogenous level of total periostin protein.

Peptide sequence around aa. 125-129 ( R-E-E-I-E), according to the protein NP_006466.2

Anti-POSTN antibody produced in rabbit has been used in western blot.

Periostin (POSTN) facilitates extracellular matrix structure and organization. It acts as a collagen chaperone and regulates type I collagen fibrillogenesis. POSTN is implicated in early stages of bone formation, tissue repair, and cell recruitment and adhesion. This protein is essential for cancer stem cell maintenance and metastasis. Increased expression of POSTN has been observed in various types of cancers including prostate, breast, lung, pancreatic, ovarian, and colorectal cancer. Hence, the postn levels can be used as a prognostic biomarker for these cancers.

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Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

rabbit

100

unconjugated

affinity isolated antibody

primary antibodies

polyclonal

buffered aqueous solution

~93 kDa

mouse, human, rat

1 mg/mL

western blot: 1:500-1:1000

IgG

(R-E-E-I-E)

NM_006475.2

Q15063

wet ice

−20℃

mouse ... Postn(50706)

Binds to heparin. Induces cell attachment and spreading and plays a role in cell adhesion. May play a role in extracellular matrix mineralization.

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12 - Non Combustible Liquids

WGK 1