Anti-Rab9 from rabbit

MFCD03097193

Rab9 is a member of the Rab family of guanosine triphosphatases (GTPases). Rab9 GTPase is localized predominantly to late endosomes. Rab proteins contain conserved regions involved in guanine nucleotide binding, and hypervariable COOH-terminal domains with a cysteine motif implicated in subcellular targeting.

synthetic peptide corresponding to amino acid residues 188-200 of human Rab9, conjugated to KLH.

Anti-Rab9 from rabbit has been used in immunoblotting and immunofluorescence.

Rab9 GTPase is required for the transport of mannose 6-phosphate receptors (MPRs) from endosomes to the trans-Golgi network (TGN). Rab9 GTPase in its GTP bound conformation binds specifically to an effector protein named p40 that stimulates the transport of mannose 6-phosphate receptors (MPRs) from endosomes to the TGN. Rab9 also interacts with the vesicle cargo selection protein TIP47 (tail-interacting protein of 47 kDa). This interaction is required for Rab9 stability on late endosomes. Anti-Rab9 antibodies may be used as a marker for late endosomes.

0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。

rabbit

200

unconjugated

affinity isolated antibody

primary antibodies

polyclonal

buffered aqueous solution

antigen ~23 kDa

rat, human, mouse

~1 mg/mL

indirect immunofluorescence: 5-10 μg/mL using rat NRK and mouse NIH3T3 cells fixed and permeabilized with 3% paraformaldehyde followed by 0.4% saponin
western blot: 5-10 μg/mL using whole extract of human A431 cells

P51151

dry ice

−20℃

human ... RAB9A(9367)
mouse ... Rab9(56382)
rat ... Rab9a(84589)

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12 - Non Combustible Liquids

WGK 3