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Anti-RUSC1 antibody produced in rabbit

产品编号:3393224
规格:affinity isolated antibody, buffered aqueous solution
包装规格:100 μG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
3393224100 μG5040
产品别名

Anti-RUSC1 antibody produced in rabbit

Anti-RUN and SH3 domain containing protein 1

Anti-NESCA

基本信息
NACRES
NA.41
Immunogen【免疫原】
RUSC1 antibody was raised against a 17 amino acid peptide from near the carboxy terminus of human RUSC1.
Features and Benefits【特点和优势】
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Linkage【联系】
The action of this antibody can be blocked using blocking peptide SBP3500106.
Physical form【外形】
Supplied at approx. 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.
产品性质
biological source【生物来源】
rabbit
Quality Level【质量水平】
100
conjugate【偶联物】
unconjugated
antibody form【抗体形式】
affinity isolated antibody
antibody product type
primary antibodies
clone【克隆】
polyclonal
form【形式】
buffered aqueous solution
species reactivity
mouse, human, rat
technique(s)
indirect ELISA: suitable
western blot: suitable
NCBI accession no.【NCBI登记号】
NP_001098673
UniProt accession no.【UniProt登记号】
Q9BVN2
shipped in【运输】
dry ice
storage temp.【储存温度】
−20℃
Gene Information
human ... RUSC1(23623)
产品说明
Target description【目标描述】
RWDD3 (RSUME), a small RWD-containing protein, has a central role in sumoylation by enhancing SUMO conjugation in the regulatory network of immune–inflammatory signals. RWDD3 increases Ikbeta sumoylation and stability. In addition, RWDD3 inhibits TNF-alpha-induced kB-LUC (Luciferase) reporter activity, showing the functional consequence of Ikbeta increased stability. RSUME-enhanced sumoylation of Ikbeta leads to the inhibition of NF-kbeta activity on two well-known inflammatory genes, IL-8 and cyclooxygenase-2 (Cox-2) and therefore may also favor anti-inflammatory pathways. Expression of RWDD3 was induced under hypoxic conditions and it has a potential role during vascularization. Both BMP-4 and RWDD3 may be interesting targets for inhibiting steps involved in pituitary tumorigenesis.
安全信息
Storage Class Code【储存分类代码】
12 - Non Combustible Liquids
WGK
WGK 2
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