Anti-S6K antibody produced in rabbit

NA.41

Ribosomal protein S6 kinase B1 (RPS6KB1) also known as S6Ka or S6K1 is an isoform of S6 kinases, which belong to AGC serine/threonine kinases of the ribosomal S6 kinase (RSK) family. S6K1 is encoded by the gene mapped to human chromosome 17q23. S6K1 is activated on phosphorylation of its domains, which include T-loop and hydrophobic motif and Ser-Pro/Thr-Pro residues at C- terminal.

The antiserum was produced against synthesized peptide derived from human S6K.

Immunogen Range: 261-310

Ribosomal protein S6 kinase B1 (RPS6KB1), or S6K1, regulates cell size and progression through cell cycle. It also inhibits pro-apoptotic protein bcl-2-associated death promoter (BAD) and promotes cell survival. mTORC1 (mammalian TORC1) phosphorylates and activates S6K1, mTORC1-S6K1 complex regulates various cellular processes, such as transcription, translation, protein and lipid synthesis, cell growth/size and cell metabolism. Overexpression of S6 kinase 1 (S6K1) leads to many disorders , including diabetes, aging, and cancer. Development of organometallic S6K1 inhibitors such as EM5 and FL772, might be a potential method for the treatment of diseases caused by aberrant activity of S6K1. The increased expression of S6K1 in obesity results in adipose tissue dysfunction via a close association with insulin resistance and inflammation development. Elevated expression of S6K1 is observed in breast cancer patients.

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Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

rabbit

unconjugated

affinity isolated antibody

primary antibodies

polyclonal

buffered aqueous solution

antigen 59 kDa

mouse, human, rat

~1 mg/mL

ELISA: 1:5000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

P23443

P23443

wet ice

−20℃

human ... RPS6KB1(6198)

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12 - Non Combustible Liquids

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