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Anti-Serine/Threonine Protein Phosphatase 2C α/β antibody produced in rabbit
| 产品编号： | 3394344 |
| 规格： | IgG fraction of antiserum, buffered aqueous solution |
| 包装规格： | 0.1 ML |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
基本信息
| MDL number | MFCD03455948 |
| NACRES | NA.44 |
| General description【一般描述】 | Among the post-translational modifications, phosphorylation is a vital regulatory mechanism of key proteins involved in specific pathways. Reverse phosphorylation has become recognized as the key process of regulation of gene expression, cellular proliferation, differentiation in Eukaryotes. Protein phosphatases, like kinases, are a class of enzymes that regulate protein phosphorylation. The serine/threonine phosphatases have been classified into four groups which include PP1, PP2A, PP2B (also termed calcineurin) and PP2C on the basis of differences in their biochemical properties. Protein phosphatases 2C (PP2Cs) are serine/threonine protein phosphatases primarily involved in stress responses. Two isoforms PP2C α and PP2Cβ are reported. Functionally, PP2C isoforms suppress TGF-β-activated kinase (TAK1), STAT3 and the nuclear factor κB pathway. Anti-Serine/Threonine Protein Phosphatase 2C α/β specifically recognizes 44-46 kDa protein phosphatase 2C α?and β?isoforms. |
| Immunogen【免疫原】 | synthetic peptide corresponding to amino acids 23-37 of the protein phosphatase 2C α/β structural subunit. |
| Application【应用】 | The recommended working dilution is 1:1000 to 1:5000 for immunoblotting using peroxidase conjugated goat anti-rabbit IgG and chemiluminescent detection. The recommended working dilution for immunoprecipitation is 1:1000 to 1:5000. The antibody is suitable for protein microarray. |
| Physical form【外形】 | Solution in phosphate buffered saline containing 0.08% sodium azide |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 200 |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | IgG fraction of antiserum |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| form【形式】 | buffered aqueous solution |
| mol wt【分子量】 | antigen 44-46 kDa |
| species reactivity | mouse, bovine, rabbit, human |
| technique(s) | immunoprecipitation (IP): suitable microarray: suitable western blot: 1:500-1:1,000 using total rat brain homogenate |
| UniProt accession no.【UniProt登记号】 | P35813 |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... PPM1A(5494), PPM1B(5495) mouse ... Ppp2ca(19052), Ppp2cb(19053) |
产品说明
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | nwg |
