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Anti-SFRP1 antibody produced in rabbit

产品编号:3394636
规格:affinity isolated antibody, buffered aqueous solution
包装规格:50 μG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
339463650 μG5040
产品别名

Anti-SFRP1 antibody produced in rabbit

FrzA

secreted frizzled related protein

sfrp-1

sarp2

基本信息
NACRES
NA.41
General description【一般描述】
SFRP1 (secreted frizzled-related protein 1) is a 35.4 kDa antagonist protein.
The encoded protein by SFRP1 gene has a cysteine-rich domain similar to the WNT-binding site of Frizzled receptors. It belongs to the WNT pathway. This gene is located on human chromosome 8p12–11.1.
The gene SFRP1 (secreted frizzled related protein 1) is mapped to human chromosome 8p22–p12, a region frequently deleted in breast cancer. It is highly expressed in normal breast tissue.
Immunogen【免疫原】
Synthetic peptide from human SFRP1.
Application【应用】
Anti-SFRP1 antibody has been used in western blot analysis.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)
Biochem/physiol Actions【生化/生理作用】
SFRP1 (secreted frizzled-related protein 1) plays a major role in the progression of several malignancies. It also plays a vital role in antagonizing Wnt signaling. Overexpression of SFRP1 is linked with apoptosis.
Secreted Frizzled-related protein 1 (SFRP1) is a secreted inhibitor of Wnt signaling pathway. DNA damage or oxidative stress causes cellular senescence, which leads to the overexpression of sfrp1. This protein induces senescence phenotypes via the inactivation of Wnt signaling and activation of the retinoblastoma (Rb) pathway. Mutations or aberrant methylation in this gene impair the induction of senescence in several cancers, including breast cancer, bladder cancer, and colorectal tumorigenesis.
Features and Benefits【特点和优势】
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form【外形】
0.02 M potassium phosphate, 0.15 M sodium chloride, pH 7.2, 0.01% sodium azide.
产品性质
biological source【生物来源】
rabbit
Quality Level【质量水平】
100
conjugate【偶联物】
unconjugated
antibody form【抗体形式】
affinity isolated antibody
antibody product type
primary antibodies
clone【克隆】
polyclonal
form【形式】
buffered aqueous solution
species reactivity
mouse, human
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
indirect immunofluorescence: suitable
western blot: suitable
UniProt accession no.【UniProt登记号】
Q8N474
shipped in【运输】
dry ice
storage temp.【储存温度】
−20℃
Gene Information
human ... SFRP1(6422)
产品说明
Disclaimer【免责声明】
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
安全信息
Storage Class Code【储存分类代码】
12 - Non Combustible Liquids
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