Anti-SMAD6 (C-terminal) antibody produced in rabbit

NA.41

SMAD family member 6 (SMAD6) is encoded by the gene mapped to human chromosome 15q22.31. The encoded protein is localized in both nuclei and cytoplasm and is expressed in variety of human tissues, including ovary. SMAD6 consists of MAD homology 2 (MH2) domain, involved in protein-protein interaction.

peptide corresponding to the C-terminal region of human SMAD6, conjugated to KLH. The corresponding sequence is identical in rat, mouse and bovine.

SMAD family member 6 (SMAD6) induces endocytosis and negatively regulates apoptosis by inhibiting transforming growth factor-β (TGF-β) signaling pathway. In addition, it also indirectly regulates stemness by inhibiting erythropoiesis in cord blood hematopoietic stem cells (HSCs). Mutation in the gene leads to congenital cardiovascular malformation (CVM). Overexpression or genetic variation of SMAD6 is associated with the development of ovarian cancer.

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

rabbit

200

unconjugated

affinity isolated antibody

primary antibodies

polyclonal

buffered aqueous solution

antigen ~60 kDa

mouse, human, rat

~1.0 mg/mL

immunoprecipitation (IP): 5-10 μg using lysates of HEK-293T cells over-expressing human SMAD6.
indirect immunofluorescence: 10-20 μg/mL using mouse 3T3 cells.
western blot: 0.5-1.0 μg/mL using whole extracts of HEK-293T cells over-expressing human SMAD6.

O43541

dry ice

−20℃

human ... SMAD6(4091)
mouse ... Smad6(17130)
rat ... Smad6(374096)

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12 - Non Combustible Liquids