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Anti-SMAD7 (N-terminal) antibody produced in rabbit
| 产品编号： | 3396498 |
| 规格： | ~1.0 mg/mL, affinity isolated antibody, suitable for western blot: 2 μg/mL |
| 包装规格： | 200 μL |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-SMAD7 (N-terminal) antibody produced in rabbit
Anti-MADH8
Anti-Mothers against DPP homolog 8
Anti-CRCS3
Anti-MAD homolog 7
Anti-MAD homolog 8
Anti-SMAD
Anti-MADH7
Anti-Mothers against DPP homolog 7
基本信息
| NACRES | NA.41 |
| General description【一般描述】 | SMAD7 (mothers against decapentaplegic homolog 7) is a Tbx1 (T-box 1) interacting gene and is encoded by the gene mapped to human chromosome 18q21.1. SMAD7 (mothers against decapentaplegic homolog 7), that binds the E3 ubiquitin ligase Smurf1/2. SMAD7 belongs to the family of inhibitory Smads (I-Smads). |
| Immunogen【免疫原】 | peptide corresponding to the N-terminal region of human SMAD7, conjugated to KLH. The corresponding sequence is identical in monkey and differs by 2 amino acids in mouse and rat. |
| Application【应用】 | Anti-SMAD7 (N-terminal) antibody produced in rabbit has been used in immunoblotting and immunofluorescence. |
| Biochem/physiol Actions【生化/生理作用】 | SMAD7 (mothers against decapentaplegic homolog 7) is a modulator of TGFβ (transforming growth factor β) signaling in immune cells which are associated with ulcerative colitis and inflammatory bowel syndrome. It plays a major role in the etiology of CRC (colorectal cancer). In addition, it also acts as a mediator of the negative feedback loop for both the TGFβ and BMP (bone morphogenetic proteins) signaling pathways. It is essential for the remodelling of pharyngeal artery and the enlargement of great vessel. In mouse, homozygous removal of Smad7 causes primarily fourth-related arch artery defects. Silencing of Smad7 in RCD (refractory coeliac disease) biopsy samples can decrease the expression of interleukin-6 and tumour necrosis factor-α. Polymorphism of this gene is associated with colorectal cancer. SMAD7 is an inhibitor of the TGFβ (transforming growth factor beta) /BMP (bone morphogenetic proteins) pathway. |
| Physical form【外形】 | Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide. |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 200 |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| form【形式】 | buffered aqueous solution |
| mol wt【分子量】 | antigen ~46 kDa |
| species reactivity | human |
| concentration【浓度】 | ~1.0 mg/mL |
| technique(s) | indirect immunofluorescence: 1-2 μg/mL using human A549 cells. western blot: 2-4 μg/mL using whole extracts of HEK-293 cells over-expressing human SMAD7. |
| UniProt accession no.【UniProt登记号】 | O15105 |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... SMAD7(4092) |
产品说明
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
