您的位置：首页 > 产品中心 > Anti-SMURF2 (N-term) antibody produced in rabbit
Anti-SMURF2 (N-term) antibody produced in rabbit
| 产品编号： | 3396719 |
| 规格： | IgG fraction of antiserum, buffered aqueous solution |
| 包装规格： | 100 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-SMURF2 (N-term) antibody produced in rabbit
Anti-Smad ubiquitination regulatory factor 2
Anti-Ubiquitin--protein ligase SMURF2
Smad-specific E3 ubiquitin ligase 2
Anti-HSMURF2
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 200 |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | IgG fraction of antiserum |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| form【形式】 | buffered aqueous solution |
| species reactivity | mouse, human |
| technique(s) | immunohistochemistry: 1:50-1:100 indirect ELISA: 1:1000 western blot: 1:100-1:500 |
| NCBI accession no.【NCBI登记号】 | NP_073576 |
| UniProt accession no.【UniProt登记号】 | Q9HAU4 |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... SMURF2(64750) |
基本信息
| General description【一般描述】 | SMURF2, a 748-amino acid ubiquitin E3 ligase that is 83% identical to SMURF1, codes for a C2-WW-HECT domain ubiquitin ligase that associates constitutively with SMAD7. Binding to SMAD7 induces export of SMURF2 and recruitment to the activated transforming growth factor-beta receptor (TGFBR), where it causes receptor and SMAD7 degradation. A strong interaction of second and third SMURF2 WW domains has been identified with SMAD1, SMAD2, and SMAD3, but not SMAD4. Western blot analysis showed that SMURF2 selectively downregulates the transcription of SMAD2 and SMAD1, but not SMAD3. The nuclear SMURF2/phosphorylated SMAD2 interaction is requires TGFB1. |
| Immunogen【免疫原】 | SMURF2 (SUF2_HUMAN, 10-46) This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human SMURF2. |
| Physical form【外形】 | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. |
产品说明
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | nwg |
