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Anti-SNCB antibody produced in chicken
| 产品编号： | 3396814 |
| 规格： | affinity isolated antibody, buffered aqueous solution |
| 包装规格： | 50 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
基本信息
| NACRES | NA.41 |
| General description【一般描述】 | SNCB (synuclein β) is a 134 amino acids protein, and is homologous to α-synuclein, which is composed of 140 amino acids. It has a putative molecular weight of 19kDa. It shares high homology to PNP14 (phosphoneuroprotein 14) found in bovines. It has a predominant expression in human brain, and is localized mainly to presynaptic nerve terminals. It is a member of synuclein proteins which are cytosolic in nature, and apart from β- and α-, also includes γ-synuclein. |
| Immunogen【免疫原】 | Recombinant β-synuclein Immunogen Sequence: GI # 4507111, sequence 1-134 |
| Application【应用】 | Anti-SNCB antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200. |
| Biochem/physiol Actions【生化/生理作用】 | β-synuclein is associated with Parkinson disease along with other neurodegenerative disorders. The β-synuclein protein is highly homologous to the α-synuclein protein and both may be able to inhibit phospholipase D2 selectively. β-synuclein is also expressed in astrocytes. Both α-synuclein and β-synuclein are abundantly expressed in the central nervous system, but β-synuclein is absent in the pathological inclusions. It is thought to have a protective role during ageing. The reduction in this protein in brain cortex is linked to a subgroup of dementia, which contains Lewy bodies. |
| Physical form【外形】 | Solution in phosphate buffered saline containing 0.02% sodium azide. |
产品性质
| biological source【生物来源】 | chicken |
| Quality Level【质量水平】 | 200 |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| form【形式】 | buffered aqueous solution |
| species reactivity | human |
| technique(s) | western blot: suitable |
| NCBI accession no.【NCBI登记号】 | NP_003076.1 |
| UniProt accession no.【UniProt登记号】 | Q16143 |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... SNCB(6620) |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
| Personal Protective Equipment【个人防护装备】 | Eyeshields, Gloves, multi-purpose combination respirator cartridge (US) |
