Anti-Snurportin 1 (N-terminal) antibody produced in rabbit

NA.41

Snurportin 1 (also known as RNA U transporter 1, SPN1 and SNUPN) comprises three known functional domains: an N-terminal importin-β binding domain (IBB) motif and trimethylguanosine (TMG) cap-binding domain. SNUPN is mapped to human chromosome 15q24.2.

Anti-Snurportin 1 (N-terminal) recognizes human snurportin 1.

Anti-Snurportin 1 (N-terminal) antibody produced in rabbit may be used in immunoblotting and immunoprecipitation.

Snurportin 1 (also known as RNA U transporter 1, SPN1 and SNUPN), mediates nuclear import of 7-methylguanosine (m⁷G) and trimethylguanosine (TMG)-capped uridine-rich small nuclear RNPs (U snRNPs), an important step in the maturation of the spliceosome. The N-terminal importin-β binding domain (IBB) motif, which binds importin β that mediates the interaction with the nuclear pore complex (NPC). The TMG cap-binding domain interacts specifically with m³G-cap but not with m⁷G-cap structures, and an ill-defined region responsible for binding to exportin 1. The active nuclear import, entry of spliceosomal U snRNPs into the nucleus by the importin b/Snurportin1/U snRNP complex does not require RanGTP. Snurportin 1 accumulates in Cajal bodies after import of U2 but not U1 snRNPs.

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

rabbit

unconjugated

affinity isolated antibody

primary antibodies

polyclonal

buffered aqueous solution

antigen ~41 kDa

antibody small pack of 25 μL

~1.0 mg/mL

immunoprecipitation (IP): 2.5-5 μg using lysates of HEK-293T cells over expressing human Snurportin 1
western blot: 1-2 μg/mL using lysates of HEK-293T cells over expressing human Snurportin 1

dry ice

−20℃

human ... SNUPN(10073)

Store at –20 ℃. For continuous use, the product may be stored at 2–8 ℃ for up to one month. For extended storage, freeze in working aliquots at –20 ℃. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.

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12 - Non Combustible Liquids