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Anti-SP1 antibody produced in rabbit
产品别名
Anti-SP1 antibody produced in rabbit
TSFP1
Transcription factor SP1
产品性质
| biological source【生物来源】 | rabbit |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| form【形式】 | buffered aqueous solution |
| mol wt【分子量】 | antigen 80 kDa |
| species reactivity | mouse, rat, human |
| concentration【浓度】 | ~1 mg/mL |
| technique(s) | ELISA: 1:20000 immunofluorescence: 1:100-1:500 immunohistochemistry: 1:50-1:100 western blot: 1:500-1:1000 |
| NCBI accession no.【NCBI登记号】 | P08047 |
| UniProt accession no.【UniProt登记号】 | P08047 |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... SP1(6667) |
基本信息
| General description【一般描述】 | Sp1 protein was the first transcription factor to be cloned and characterized. It was first detected in HeLa cells on the basis of its ability to activate the SV40 early promoter transcription. Analysis of structure and function has revealed that Sp1 can be separated into discrete functional domains. The DNA-binding domain consists of three zinc fingers that specifically bind to the GC-box element. Anti-SP1 Antibody detects endogenous levels of total SP1 protein. |
| Immunogen【免疫原】 | The antiserum was produced against synthesized peptide derived from human SP1. Immunogen Range: 706-755 |
| Biochem/physiol Actions【生化/生理作用】 | Sp1 protein was shown to recognize and bind selectively to a GC-rich consensus sequence (GC-box: GGGCGG or CACCC) that presents in the promoter of several important cellular genes, including Simian vacuolating virus 40 (SV40) early, human immunodeficiency virus-1 (HIV-1), platelet-derived growth factor subunit B (PDGF-B), Myc, c-Src etc. In addition to transcription, Sp1 function has been linked to cell growth, cancer and Huntington disease. |
| Features and Benefits【特点和优势】 | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| Physical form【外形】 | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | nwg |
