Anti-SPRY2 antibody produced in rabbit

NA.41

The gene SPRY2 (Sprouty homolog 2) is mapped to human chromosome 13q31.1. SPRY2 localizes in the cytoplasm and co-localizes with microtubules.

Synthetic peptide directed towards the N terminal region of human SPRY2

Anti-SPRY2 antibody produced in rabbit is suitable for western blotting at a concentration of 1.0μg/ml.

Sprouty proteins are inhibitors of receptor tyrosine kinase signaling proteins and mediators of organogenesis, branching of lung alveoli and endothelial tubes. They inhibit the activity of Ras/Erk pathway. SPRY2 (Sprouty homolog 2) is bimodal regulator of epidermal growth factor receptor (EGFR)/mitogen-activated protein kinase signaling. SPRY2 is down-regulated in epithelial ovarian cancer. Down-regulation of SPRY2 in high-grade serous ovarian carcinoma promotes EGF-induced E-cadherin levels, thereby resulting in cell invasion.

Synthetic peptide located within the following region: MEARAQSGNGSQPLLQTPRDGGRQRGEPDPRDALTQQVHVLSLDQIRAIR

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

rabbit

100

unconjugated

affinity isolated antibody

primary antibodies

polyclonal

buffered aqueous solution

35 kDa

rat, mouse, pig, human, dog

0.5 mg - 1 mg/mL

immunohistochemistry: suitable
western blot: suitable

NP_005833

O43597

wet ice

−20℃

human ... SPRY2(10253)

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12 - Non Combustible Liquids

WGK 3