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Anti-St14 antibody produced in rabbit
产品别名
Anti-St14 antibody produced in rabbit
Anti-HAI
Anti-MT-SP1
Anti-MTSP1
Anti-suppression of tumorigenicity 14 (colon carcinoma)
Anti-TADG-15
Anti-MTSP-1
Anti-PRSS14
Anti-SNC19
基本信息
| NACRES | NA.41 |
| General description【一般描述】 | Suppression of tumorigenicity 14 (colon carcinoma) (ST14) is an intergral membrane serine protease that forms a complex with HAI-1. It is known to inhibit cell growth and functions as a target for miR-27b. Mutations in ST14 have been linked to icthyosis. Rabbit Anti-ST14 antibody recognizes human, mouse, rat, bovine, and rabbit ST14. |
| Immunogen【免疫原】 | Synthetic peptide directed towards the C terminal region of human ST14 |
| Application【应用】 | Rabbit Anti-ST14 antibody is suitable for western blot applications at a concentration of 0.25 μg/ml and for IHC at 4-8 μg/ml. |
| Biochem/physiol Actions【生化/生理作用】 | ST14 is an epithelial-derived, integral membrane serine protease. This protease forms a complex with the Kunitz-type serine protease inhibitor, HAI-1, and is found to be activated by sphingosine 1-phosphate. This protease has been shown to cleave and activate hepatocyte growth factor/scattering factor, and urokinase plasminogen activator, which suggest the function of this protease as an epithelial membrane activator for other proteases and latent growth factors. The expression of this protease has been associated with breast, colon, prostate, and ovarian tumors, which implicates its role in cancer invasion, and metastasis. |
| Sequence【序列】 | Synthetic peptide located within the following region: SHVFPAGKAIWVTGWGHTQYGGTGALILQKGEIRVINQTTCENLLPQQIT |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| mol wt【分子量】 | 95 kDa |
| species reactivity | human, bovine, horse, rat, pig, mouse |
| packaging【包装】 | pkg of 100 μL buffered aqueous solution pkg of 50 μg lyophilized powder |
| concentration【浓度】 | 0.5 mg - 1 mg/mL |
| technique(s) | immunohistochemistry: suitable western blot: suitable |
| NCBI accession no.【NCBI登记号】 | NP_068813 |
| UniProt accession no.【UniProt登记号】 | Q9Y5Y6 |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... ST14(6768) |
产品说明
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 3 |
