Anti-STIM2 兔抗

NA.41

STIM (stromal interaction molecule) proteins are conserved single-pass transmembrane protein. The three STIM proteins, STIM1, STIM2 and D-Stim, are ubiquitously expressed proteins composed of a single SAM (sterile α-motif) domain and an unpaired EF hand within the highly conserved extracellular region and coiled-coil domains that are conserved in structure and position within the cytoplasmic region. Significant divergence between these proteins was found only at the extreme C-termini. STIM proteins are modified by phosphorylation and N-linked glycosylation.

synthetic peptide corresponding to amino acids 812-833 of human STIM2, conjugated to KLH. The corresponding sequence is identical in rat and mouse.

Anti-STIM2 antibody produced in rabbit has been used in western blotting.

STIM (stromal interaction molecule) required for the regulation of store-operated Ca²⁺ influx. Store-operated calcium entry is mediated by Ca²⁺ release-activated Ca²⁺ (CRAC) channels, following Ca²⁺ depletion from the endoplasmic reticulum (ER) stores. This process is crucial for gene transcription, proliferation and cytokine release. STIM2 is an inhibitor of STIM1-mediated store-operated Ca²⁺ entry. STIM2 co-localizes with STIM1 in punctae upon store depletion, and coprecipitates with STIM1 from cell lysates, suggesting that they may play a coordinated role in controlling Ca²⁺ entry.

0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。

rabbit

200

unconjugated

affinity isolated antibody

primary antibodies

polyclonal

buffered aqueous solution

antigen ~100 kDa

human, rat, mouse

~1.0 mg/mL

western blot: 0.1-0.2 μg/mL using whole extract of mouse brain
western blot: 0.5-1.0 μg/mL using rat brain
western blot: 0.5-1.0 μg/mL using whole extracts of human U87 cells

Q9P246

dry ice

−20℃

human ... STIM2(57620)
mouse ... Stim2(116873)
rat ... Stim2(117087)

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