您的位置:首页 > 产品中心 > Anti-TDP-43 (N-terminal region) antibody produced in rabbit
Anti-TDP-43 (N-terminal region) antibody produced in rabbit
![](/image/daily/2022/03/25/135918_551799_proimg_3400099.jpg)
产品编号: | 3400099 |
规格: | ~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution |
包装规格: | 200 μL |
产品类别: | 进口试剂 |
品牌: | Sigma-Aldrich |
优惠价: | 立即咨询 |
产品别名
Anti-TDP-43 (N-terminal region) antibody produced in rabbit
Anti-TARDBP
Anti-TAR DNA binding protein 43
Anti-ALS10
Anti-TARDP43
基本信息
NACRES | NA.41 |
General description【一般描述】 | TDP-43 (TAR DNA binding protein, TARDP) belongs to the family of heterogeneous nuclear ribonucleoproteins (hnRNPs) that bind single stranded RNA. TDP-43 is predominantly localized to the nucleus. |
Application【应用】 | Anti-TDP-43 (N-terminal region) antibody produced in rabbit has been used in:
|
Biochem/physiol Actions【生化/生理作用】 | TDP-43 is also involved in mediating the transcription regulation of human immune deficiency virus (HIV). TDP-43 has been identified as the major ubiquinated component of cytoplasmic inclusions in frontotemporal lobe degeneration subtype FTLD-U and amyotrophic lateral sclerosis (ALS). Pathological TDP-43 forms abnormal inclusions in neuronal perikarya and neurites, indicating that redistribution of TDP-43 to the cytoplasm is a pathogenic mechanism. Several pathogenic TDP43 mutations have been identified in familial ALS, causing aberrant cleavage of TDP-43 to C-terminal fragments, and predisposing nuclear TDP-43 to redistribute to the cytoplasm and form pathological aggregates. Abnormal phosphorylation of TDP-43 at Ser409/410 has also been observed in frontotemporal lobar degeneration and amyotrophic lateral sclerosis (FTLD-U and ALS) suggesting a toxic gain of function leading to apoptosis. |
Physical form【外形】 | Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide. |
产品性质
biological source【生物来源】 | rabbit |
conjugate【偶联物】 | unconjugated |
antibody form【抗体形式】 | affinity isolated antibody |
antibody product type | primary antibodies |
clone【克隆】 | polyclonal |
form【形式】 | buffered aqueous solution |
mol wt【分子量】 | antigen ~43 kDa |
species reactivity | human, mouse |
concentration【浓度】 | ~1.0 mg/mL |
technique(s) | immunohistochemistry: 5-10 μg/mL using human or mouse kidney indirect immunofluorescence: 5-10 μg/mL using HepG2 cells western blot: 1.5-3.0 μg/mL using HepG2 cell lysates |
UniProt accession no.【UniProt登记号】 | Q13148 |
shipped in【运输】 | dry ice |
storage temp.【储存温度】 | −20℃ |
Gene Information | human ... TARDBP(23435) mouse ... Tardbp(230908) |
产品说明
Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |