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Anti-TDP2 antibody produced in rabbit
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产品别名
Anti-TDP2 antibody produced in rabbit
EAPII
hTDP2
EAP2
AD022
TTRAP
基本信息
NACRES | NA.41 |
General description【一般描述】 | Tyrosyl DNA phosphodiesterase-2 (TDP2) is a multi-functional protein and is also called as TTRAP (TNF receptor-associated protein). It is a 5′- tyrosyl DNA phosphodiesterase that belongs to the PML NB (promyelocytic leukemia nuclear body) protein family. TDP2 is mapped to human chromosome 6p22. |
Specificity【特异性】 | The antibody detects endogenous levels of total TDP2 protein. |
Immunogen【免疫原】 | Synthetic peptide corresponding to a region derived from internal residues of human tyrosyl-DNA phosphodiesterase 2 |
Biochem/physiol Actions【生化/生理作用】 | Chromosomal translocations stimulated by DNA topoisomerase II at the time of gene transcription is repressed by tyrosyl DNA phosphodiesterase-2 (TDP2). It is essential to preserve the chromosome stability in human cells. TDP2 participates in cell proliferation, apoptosis and the repair of DNA damage. It promotes cell cycle arrest and apoptosis in osteosarcoma cells. |
Features and Benefits【特点和优势】 | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
Physical form【外形】 | Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol. |
产品性质
biological source【生物来源】 | rabbit |
Quality Level【质量水平】 | 100 |
antibody form【抗体形式】 | affinity isolated antibody |
antibody product type | primary antibodies |
clone【克隆】 | polyclonal |
form【形式】 | buffered aqueous solution |
mol wt【分子量】 | 41 kDa |
species reactivity | human, mouse |
concentration【浓度】 | 2.6 mg/mL |
technique(s) | immunohistochemistry: 1:50- 1:200 western blot: 1:200-1:1000 (Cell Lysate) |
isotype【同位素/亚型】 | IgG |
accession no.【登记号】 | NP_057698.2 |
UniProt accession no.【UniProt登记号】 | O95551 |
shipped in【运输】 | wet ice |
storage temp.【储存温度】 | −20℃ |
Gene Information | human ... TDP2(51567) |
产品说明
Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
WGK | WGK 1 |