Anti-Tensin 1 (C-terminal region) antibody produced in rabbit

NA.41

Tensins are a new family of focal adhesion proteins that link between the extracellular matrix (ECM) and the cytoskeleton via integrins. The tensin family includes four members: tensin1-4, encoded by different genes. Tensins are multidomain proteins consisting of homologous C1, protein tyrosine phosphatase (PTPase), C2, SH2 and PTB domains. Tensin 1 (also known as TNS1), shares extensive homology with tensin 2 and tensin 3 at its N- and C-terminal regions. Tensin 1 mRNA is broadly expressed in mouse embryo and various human tissues and is localized to focal adhesions.

synthetic peptide corresponding to a sequence located near the C-terminus of human tensin1, conjugated to KLH. The corresponding sequence is identical in rat and mouse tensin1.

Anti-Tensin 1 (C-terminal region) antibody produced in rabbit has been used in immunoblotting and immunofluorescence.

Tensin 1 plays an important role in regulating cell polarization, shape, motility and invasion. Tensin 1 is cleaved by calpain II, a focal adhesion protease, suggesting that tensin 1 plays important roles in organizing the actin cytoskeleton and mediating signal transduction.

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

rabbit

200

unconjugated

affinity isolated antibody

primary antibodies

polyclonal

buffered aqueous solution

antigen 225 kDa (rat)
antigen ~150 kDa (Human)

chicken, human, rat

recombinant expression
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~1.5 mg/mL

indirect immunofluorescence: 2-4 μg/mL using chicken embryo fibroblast cells
western blot: 1-2 μg/mL using HEK-293T cell lysates overexpressing human tensin1
western blot: 1.5-3.0 μg/mL using lysates of A10 cells

Q9HBL0

dry ice

−20℃

human ... TNS1(7145)
rat ... Tns1(301509)

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