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Anti-Tensin 1 (C-terminal region) antibody produced in rabbit
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产品别名
Anti-Tensin 1 (C-terminal region) antibody produced in rabbit
Anti-TNS
Anti-TNS1
基本信息
NACRES | NA.41 |
General description【一般描述】 | Tensins are a new family of focal adhesion proteins that link between the extracellular matrix (ECM) and the cytoskeleton via integrins. The tensin family includes four members: tensin1-4, encoded by different genes. Tensins are multidomain proteins consisting of homologous C1, protein tyrosine phosphatase (PTPase), C2, SH2 and PTB domains. Tensin 1 (also known as TNS1), shares extensive homology with tensin 2 and tensin 3 at its N- and C-terminal regions. Tensin 1 mRNA is broadly expressed in mouse embryo and various human tissues and is localized to focal adhesions. |
Immunogen【免疫原】 | synthetic peptide corresponding to a sequence located near the C-terminus of human tensin1, conjugated to KLH. The corresponding sequence is identical in rat and mouse tensin1. |
Application【应用】 | Anti-Tensin 1 (C-terminal region) antibody produced in rabbit has been used in immunoblotting and immunofluorescence. |
Biochem/physiol Actions【生化/生理作用】 | Tensin 1 plays an important role in regulating cell polarization, shape, motility and invasion. Tensin 1 is cleaved by calpain II, a focal adhesion protease, suggesting that tensin 1 plays important roles in organizing the actin cytoskeleton and mediating signal transduction. |
Physical form【外形】 | Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide. |
产品性质
biological source【生物来源】 | rabbit |
Quality Level【质量水平】 | 200 |
conjugate【偶联物】 | unconjugated |
antibody form【抗体形式】 | affinity isolated antibody |
antibody product type | primary antibodies |
clone【克隆】 | polyclonal |
form【形式】 | buffered aqueous solution |
mol wt【分子量】 | antigen 225 kDa (rat) antigen ~150 kDa (Human) |
species reactivity | chicken, human, rat |
enhanced validation【增强验证】 | recombinant expression Learn more about Antibody Enhanced Validation |
concentration【浓度】 | ~1.5 mg/mL |
technique(s) | indirect immunofluorescence: 2-4 μg/mL using chicken embryo fibroblast cells western blot: 1-2 μg/mL using HEK-293T cell lysates overexpressing human tensin1 western blot: 1.5-3.0 μg/mL using lysates of A10 cells |
UniProt accession no.【UniProt登记号】 | Q9HBL0 |
shipped in【运输】 | dry ice |
storage temp.【储存温度】 | −20℃ |
Gene Information | human ... TNS1(7145) rat ... Tns1(301509) |
产品说明
Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |