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Anti-TIMELESS antibody produced in rabbit
产品别名
Anti-TIMELESS antibody produced in rabbit
Anti-Timeless homolog (Drosophila)
基本信息
| NACRES | NA.41 |
| General description【一般描述】 | Timeless is a highly conserved protein that modulates cell survival and morphogenesis. It is also involved in enhancing DNA polymerase functions and the maintenance of telomere length. Studies have revealed that TIMELESS modulates phase advancing of the circadian clock in response to DNA damage. Furthermore, it has been implicated in carcinogenesis. Rabbit Anti-TIMELESS antibody recognizes canine, human, mouse, rat, and bovine TIMELESS. |
| Immunogen【免疫原】 | Synthetic peptide directed towards the N terminal region of human TIMELESS |
| Application【应用】 | Rabbit Anti-TIMELESS antibody can be used for western blot applications at a concentration of 0.25 μg/ml. It can also be used for IHC assays at 4-8 μg/ml. |
| Biochem/physiol Actions【生化/生理作用】 | The human Timeless protein interacts with both the circadian clock protein cryptochrome 2 and with the cell cycle checkpoint proteins Chk1 and the ATR-ATRIP complex and plays an important role in the DNA damage checkpoint response. Down-regulation of Timeless in human cells seriously compromises replication and intra-S checkpoints, indicating an intimate connection between the circadian cycle and the DNA damage checkpoints that is in part mediated by the Timeless protein. |
| Sequence【序列】 | Synthetic peptide located within the following region: IGERDLIFHKGLHNLRNYSSDLGKQPKKVPKRRQAARELSIQRRSALNVR |
| Physical form【外形】 | Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| form【形式】 | buffered aqueous solution |
| mol wt【分子量】 | 139 kDa |
| species reactivity | human |
| concentration【浓度】 | 0.5 mg - 1 mg/mL |
| technique(s) | immunohistochemistry: suitable western blot: suitable |
| NCBI accession no.【NCBI登记号】 | NP_003911 |
| UniProt accession no.【UniProt登记号】 | Q9UNS1 |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... TIMELESS(8914) |
产品说明
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 3 |
