您的位置：首页 > 产品中心 > Anti-TIMP1 antibody produced in rabbit
Anti-TIMP1 antibody produced in rabbit
产品别名
Anti-TIMP1 antibody produced in rabbit
EPA
COLLAGENASE INHIBITOR
HUMAN
tissue inhibitor of metalloproteinase 1 (erythroid potentiating activity
HCI
基本信息
| MDL number | MFCD01322705 |
| NACRES | NA.41 |
| General description【一般描述】 | The TIMP1 (TIMP metallopeptidase inhibitor 1) gene is mapped to human chromosome Xp11.3. Tissue inhibitors of metalloproteinase 1 (TIMP1) is a member of TIMPs protein family. It is widely expressed in most of the human tissues and body fluids. TIMP1 is a wedge shaped protein with five β-strands, a central helical region representing the interface of the two domains and a C-terminal β-structure. |
| Immunogen【免疫原】 | The antiserum was produced against synthesized peptide derived from human TIMP1. Immunogen Range: 61-110 |
| Application【应用】 | Anti-TIMP1 antibody produced in rabbit has been used in western blotting. |
| Biochem/physiol Actions【生化/生理作用】 | TIMP1 (TIMP metallopeptidase inhibitor 1) mediates the communication between tumor cells and cancer associated fibroblasts and contributes to tumor progression in condition such as hepatocellular carcinoma. The encoded protein is a cytokine tissue inhibitor. Timp1 regulates the activity of matrix metalloproteinases (MMP) especially MMP-8 and -9. Imbalance in Timp1 levels lowers the fibrotic material in the extracellular matrix and results in inflammation. This might contribute to the pathogenesis of myocardial fibrosis, atherosclerosis and acute coronary syndrome. Timp1 level serves as an important biomarker in the development of sepsis. |
| Features and Benefits【特点和优势】 | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| Physical form【外形】 | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
产品性质
| biological source【生物来源】 | rabbit |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| form【形式】 | buffered aqueous solution |
| mol wt【分子量】 | antigen 23 kDa |
| species reactivity | mouse, human, rat |
| concentration【浓度】 | ~1 mg/mL |
| technique(s) | ELISA: 1:10000 western blot: 1:500-1:1000 |
| NCBI accession no.【NCBI登记号】 | P01033 |
| UniProt accession no.【UniProt登记号】 | P01033 |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... TIMP1(7076) |
产品说明
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | nwg |
