您的位置:首页 > 产品中心 > Anti-UCHL5 antibody produced in mouse
Anti-UCHL5 antibody produced in mouse
产品编号: | 3404121 |
规格: | IgG fraction of antiserum, buffered aqueous solution |
包装规格: | 50 μG |
产品类别: | 进口试剂 |
品牌: | Sigma-Aldrich |
优惠价: | 立即咨询 |
产品别名
Anti-UCHL5 antibody produced in mouse
Anti-CGI-70
Anti-UCH37
基本信息
NACRES | NA.41 |
General description【一般描述】 | UCHL5 (ubiquitin C-terminal hydrolase L5) is a cysteine protease and belongs to ubiquitin-specific proteases and ubiquitin C-terminal hydrolases family. The encoded protein is a deubiquitinating enzyme that is connected with the 26S proteasome. The active site of the protein consists of a six-stranded antiparallel β-sheet at the center and α-helices are flanked on its either sides. The gene is found to be expressed in the cytoplasm as well as the nucleus. |
Immunogen【免疫原】 | UCHL5 (AAH25369.1, 1 a.a. ~ 326 a.a) full-length human protein. Sequence MTGNAGEWCLMESDPGVFTELIKGFGCRGAQVEEIWSLEPENFEKLKPVHGLIFLFKWQPGEEPAGSVVQDSRLDTIFFAKQVINNACATQAIVSVLLNCTHQDVHLGETLSEFKEFSQSFDAAMKGLALSNSDVIRQVHNSFARQQMFEFDTKTSAKEEDAFHFVSYVPVNGRLYELDGLREGPIDLGACNQDDWISAVRPVIEKRIQKYSEGEIRFNLMAIVSDRKMIYEQKIAELQRQLAEEPMDTDQGNSMLSAIQSEVAKNQMLIEEEVQKLKRYKIENIRRKHNYLPFIMELLKTLAEHQQLIPLVEKFEKHFEKTLLGK |
Biochem/physiol Actions【生化/生理作用】 | UCHL5 (ubiquitin C-terminal hydrolase L5) regulates proteasome activity by deubiquitination. It is known to serve as biomarker in the prognosis of cancers such as rectal cancer and pancreatic ductal adenocarcinoma. Unlike other members of the ubiquitin carboxy-terminal hydrolase family, UCHL5 might be able to process polyubiquitin chain. UCHL5 is necessary for correct cell cycle progression. Downregulation of the gene leads to a halt in the cell cycle at G0/G1. |
Physical form【外形】 | Solution in phosphate buffered saline, pH 7.4 |
产品性质
Quality Level【质量水平】 | 100 |
biological source【生物来源】 | mouse |
conjugate【偶联物】 | unconjugated |
antibody form【抗体形式】 | IgG fraction of antiserum |
antibody product type | primary antibodies |
clone【克隆】 | polyclonal |
form【形式】 | buffered aqueous solution |
species reactivity | human |
technique(s) | western blot: 1 μg/mL |
UniProt accession no.【UniProt登记号】 | Q9Y5K5 |
shipped in【运输】 | dry ice |
storage temp.【储存温度】 | −20℃ |
Gene Information | human ... UCHL5(51377) |
产品说明
Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |