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Anti-WDR77 antibody produced in rabbit
| 产品编号： | 3405628 |
| 规格： | whole antiserum, buffered aqueous solution |
| 包装规格： | 100 μL |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-WDR77 antibody produced in rabbit
HKMT1069
Nbla10071
MGC2722
MEP50
p44
RP11-552M11.3
基本信息
| NACRES | NA.41 |
| General description【一般描述】 | WDR77 is a component of the 20S PRMT5 (MIM 604045)-containing methyltransferase complex, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins (see MIM 601061). This modification targets Sm proteins to the survival of motor neurons (SMN) complex (see MIM 600354) for assembly into small nuclear ribonucleoprotein core particles (Friesen et al., 2002 [PubMed 11756452]).[supplied by OMIM |
| Immunogen【免疫原】 | WDR77 (NP_077007.1, 1 a.a. ~ 342 a.a) full-length human protein. Sequence MRKETPPPLVPPAAREWNLPPNAPACMERQLEAARYRSDGALLLGASSLSGRCWAGSLWLFKDPCAAPNEGFCSAGVQTEAGVADLTWVGERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFRSQAHRDFVRDATWSPLNHSLLTTVGWDHQVVHHVVPTEPLPAPGPASVTE |
| Biochem/physiol Actions【生化/生理作用】 | WD repeat domain 77 (WDR77) associates with protein arginine methyltransferase 5 (PRMT5) in a methylosome complex and stimulates its histone methyltransferase activity. It also binds to androgen receptors and modulates its target genes in prostate epithelial cells and prostate cancer. |
| Physical form【外形】 | Clear solution |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | whole antiserum |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| form【形式】 | buffered aqueous solution |
| species reactivity | human |
| technique(s) | western blot: 1:500-1:1000 |
| NCBI accession no.【NCBI登记号】 | NM_024102.2 |
| UniProt accession no.【UniProt登记号】 | Q9BQA1 |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... WDR77(79084) |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
