阿塞那平马来酸盐

C₁₇H₁₆ClNO ·C₄H₄O₄

401.84

288-064-8

329770943

NA.77

Asenapine maleate acts as an antimanic. It belongs to the family of dibenzoxepinopyrrolidines. Asenapine is considered to be a weak inhibitor of cytochrome P450 2D6 (CYP2D6). It increases the level of dopamine, norepinephrine and acetylcholine in brain.

Asenapine maleate has been used as a stressor in studying the Fos expression in forebrain structures of rat models.
Asenapine maleate is a serotonin 5-HT and dopamine D2 receptor antagonist. Asenapine maleate can be used to treat schizophrenia and bipolar mania.

Asenapine maleate is a 5-HT receptor antagonist (5-HT_1A,_1B, 5-HT_{2A, 2B, 2C}, 5-HT_5A, 5-HT₆ and 5-HT₇), a D2 antagonist, and an antipsychotic.

This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

100

≥98% (HPLC)

powder

white to off-white

H₂O: ≥10 mg/mL

Merck & Co., Inc., Kenilworth, NJ, U.S.

2-8℃

OC(=O)\C=C/C(O)=O.CN1C[C@H]2[C@H](C1)c3cc(Cl)ccc3Oc4ccccc24

1S/C17H16ClNO.C4H4O4/c1-19-9-14-12-4-2-3-5-16(12)20-17-7-6-11(18)8-13(17)15(14)10-19;5-3(6)1-2-4(7)8/h2-8,14-15H,9-10H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1-/t14-,15-;/m1./s1

GMDCDXMAFMEDAG-CHHFXETESA-N

10, 50 mg in glass bottle

GHS06,GHS09

Danger

H301 - H315 - H319 - H335 - H400

P273 - P301 + P310 + P330 - P302 + P352 - P305 + P351 + P338

Acute Tox. 3 Oral - Aquatic Acute 1 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Respiratory system

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK 3